Tag: pubmed

J Health Popul Nutr. 2025 Feb 11;44(1):37. doi: 10.1186/s41043-024-00722-0.

ABSTRACT

BACKGROUND: This study aims to determine the factors affecting the poverty rate among the households in question by region, the western, central, and eastern regions underwent research separately.

METHODS: This study uses the ordered discrete choice models: the heteroskedastic ordered logistic regression, generalized ordered probit, and partial proportional odds models.

RESULTS: Based on the findings of the data, statistically significant relationships between the variables; age, gender, levels of education, marital status, the number of equivalent individuals within the household, the existence of individuals under the age of 5 within the household, the presence of individuals over the age of 65 within the household, working status, the number of working individuals within the household, financial difficulty, the presence of income generated through real estate (rent) or securities, residential homeownership, chronic diseases, and the year of data collection were spotted.

CONCLUSIONS: Poverty is a multidimensional concept that can emerge due to several economic and social factors. Therefore, the policies that can be developed to reduce poverty can vary. To solve the problem of poverty, countries identify the factors that cause poverty and develop policies accordingly. Factors influencing household poverty levels across regions in Türkiye were identified, and several policy recommendations aimed to alleviate poverty were offered, considering the results achieved in this study. Given the results, Non-Governmental Organizations (NGOs) must implement practical projects that provide in-kind and cash assistance to those in need, offer employment opportunities, and improve the productivity of the impoverished. Continuous aid to the poor without expecting anything in return encourages them to be lazy, which may have a negative effect by increasing their dependency on getting help. In our country, an institutional monitoring mechanism should be established to measure the effectiveness of the in-kind and cash aids provided by central government institutions, local governments, and various non-governmental organizations in the fight against poverty.

PMID:39934907 | DOI:10.1186/s41043-024-00722-0

Perioper Med (Lond). 2025 Feb 11;14(1):18. doi: 10.1186/s13741-025-00500-4.

ABSTRACT

OBJECTIVE: This study aims to investigate the effects of remimazolam on postoperative melatonin secretion, sleep rhythm, and postoperative delirium (POD) in elderly patients undergoing spinal surgery.

METHODS: We selected 120 elderly patients scheduled for elective spinal surgery (lumbar interbody fusion via a posterior approach) under general anaesthesia from November 2023 to January 2024. They were divided into 2 groups according to medication, the remimazolam group (R group) and the propofol group (P group), with 60 patients in each group. The R group received an induction dose of remimazolam 0.2 ~ 0.3 mg/kg, followed by a continuous infusion of remimazolam at 0.1-0.2 mg/kg/h for maintenance. The P group received an induction dose of propofol 1.5 ~ 2.0 mg/kg, followed by a continuous infusion of propofol at 4-6 mg/kg/h for maintenance. Melatonin and cortisol concentrations were measured at 04:00 on the day of surgery and postoperative days 1, 2, and 3. The Pittsburgh Sleep Quality Index (PSQI) and resting visual analog scale (VAS) pain scores were recorded on the day before surgery, and on postoperative days 1 and 2, as well as prior to discharge. Additionally, we documented extubation time, PACU stay duration, total and effective button presses on the analgesia pump, instances of supplemental analgesia, and occurrence of complications.

RESULTS: Compared to the P group, the R group exhibited significantly shorter extubation time and PACU stay duration (P < 0.05). On postoperative days 1 and 2 at 04:00, melatonin concentrations were significantly higher, cortisol concentrations were significantly lower, and PSQI scores were significantly reduced in the R group (P < 0.05). The incidence of POD and postoperative sleep disturbance (POSD) was also significantly lower in the R group (P < 0.05). Furthermore, on postoperative day 1, the PSQI and resting VAS pain scores in the R group were significantly lower compared to the P group (P < 0.05). There were no statistically significant differences between the two groups in terms of surgery duration, anaesthesia duration, total and effective analgesia pump button presses, supplemental analgesia rates, intraoperative hypotension, or incidences of postoperative nausea, vomiting, dizziness, and respiratory depression (P > 0.05).

CONCLUSION: The use of remimazolam in elderly patients undergoing spinal surgery has a minimal impact on postoperative melatonin and cortisol secretion rhythms and sleep patterns, and may reduce the incidence of POD and alleviate postoperative sleep disturbances.

PMID:39934906 | DOI:10.1186/s13741-025-00500-4

Antimicrob Resist Infect Control. 2025 Feb 11;14(1):10. doi: 10.1186/s13756-025-01518-5.

ABSTRACT

BACKGROUND: The emergence of antimicrobial resistance in Gram-negative bacteria (GNB) is a major global concern. Ceftazidime-avibactam (CAZ-AVI) has been identified as a potential treatment option for complicated infections.

OBJECTIVES: This meta-analysis aimed to evaluate the global resistance proportions of GNB to CAZ-AVI comprehensively.

METHODS: Studies were searched in Scopus, PubMed, and EMBASE (until September 2024), and statistical analyses were conducted using STATA software (version 20.0).

RESULTS: CAZ-AVI resistance proportions were determined in 136 studies, with 25.8% (95% CI 22.2-29.7) for non-fermentative gram-negative bacilli and 6.1% (95% CI 4.9-7.4) for Enterobacterales. The CAZ-AVI resistance proportion significantly increased from 5.6% (95% CI 4.1-7.6) of 221,278 GNB isolates in 2015-2020 to 13.2% (95% CI 11.4-15.2) of 285,978 GNB isolates in 2021-2024. Regionally, CAZ-AVI resistance was highest in Asia 19.3% (95% CI 15.7-24.23.4), followed by Africa 13.6% (95% CI 5.6-29.2), Europe 11% (95% CI 7.8-15.2), South America 6.1% (95% CI 3.2-11.5) and North America 5.3% (95% CI 4.2-6.7). Among GNB resistance profiles, colistin-resistant isolates and XDR isolates exhibited the highest resistance proportions (37.1%, 95% CI 14-68 and 32.1%, 95% CI 18.5-49.6), respectively), followed by carbapenem-resistant isolates and MDR isolates [(25.8%, 95% CI 22.6-29.3) and (13%, 95% CI 9.6, 17.3)].

CONCLUSION: A high proportion of GNB isolates from urinary tract infections remained susceptible to CAZ-AVI, indicating its potential as a suitable treatment option. However, the increasing resistance trends among GNB are concerning and warrant continuous monitoring to maintain CAZ-AVI’s effectiveness against GNB infections.

PMID:39934901 | DOI:10.1186/s13756-025-01518-5

Perioper Med (Lond). 2025 Feb 11;14(1):19. doi: 10.1186/s13741-025-00499-8.

ABSTRACT

OBJECTIVE: This study aimed to evaluate the effect of perioperative real-time information sharing on family members’ anxiety in patients undergoing elective thoracoscopic lobectomy and to explore the potential role of information sharing in reducing anxiety levels among family members.

METHODS: This study was a prospective, single-center, well-designed randomized controlled trial (RCT), ensuring methodological rigor, which included family members of patients undergoing elective thoracoscopic lobectomy. Participants were randomly assigned to either the experimental group (real-time information-sharing group) or the control group (routine information communication group). Anxiety levels were assessed at multiple time points, including preoperative (T-1), intraoperative (T1, T2, T3, T4), and postoperative (T5, T6) stages, using widely used anxiety scales: the Self-Rating Anxiety Scale (SAS), the Hospital Anxiety and Depression Scale (HADS), and the Generalized Anxiety Disorder 7 (GAD-7). Statistical analysis was performed using independent sample t-tests, with statistical significance set at P < 0.05 based on a predefined threshold.

RESULTS: At several key time points (T0, T1, T2, T3, T4, T5), family members in the experimental group showed significantly lower anxiety scores compared to those in the control group (P < 0.05). Notably, at T1 (when the patient entered the operating room) and T2 (30 min after the surgery began), the GAD-7 scores of the experimental group were significantly lower than those in the control group (T = 2.98, P = 0.003; T = 3.45, P = 0.001). The experimental group also had significantly lower SAS and HADS scores at time points T-1, T0, T1, T2, T3, and T4 compared to the control group.

CONCLUSION: Perioperative real-time information sharing has been shown to significantly reduce anxiety levels in family members of patients undergoing elective thoracoscopic lobectomy, particularly during the early stages of surgery, such as when the patient enters the operating room and 30 min after the surgery begins. Real-time information sharing may serve as an effective intervention to improve the psychological well-being of family members and is worth promoting in clinical practice.

PMID:39934883 | DOI:10.1186/s13741-025-00499-8

Trials. 2025 Feb 11;26(1):49. doi: 10.1186/s13063-024-08684-8.

ABSTRACT

Platform trials have become widely adopted across multiple disease areas over recent years, however, guidelines for operationalising these trials have not kept pace. We outline a series of documents that summarise the statistical components, and implicit processes, of the Staphylococcus aureus Network Adaptive Platform (SNAP) trial to provide an informal template for other researchers and reviewers of platform trials. We briefly summarise the content and role of the core protocol, statistical appendix, domain-specific appendices, simulation report, statistical implementation guides, data safety and monitoring committee (DSMC) reports, and domain-specific statistical analysis plans and final reports, and a transparent governance structure that ensures separate blinded and unblinded statistical teams. In the absence of guidelines or checklists for platform trial statistical documents, we hope to provide useful guidance to others in terms of what has worked so far for the SNAP trial, stimulate discussion, and inform a future consensus.Trial registration NCT05137119 . Registered on 30 November 2021.

PMID:39934879 | DOI:10.1186/s13063-024-08684-8

BMC Psychol. 2025 Feb 11;13(1):112. doi: 10.1186/s40359-025-02412-w.

ABSTRACT

BACKGROUND: Research on student engagement has garnered significant interest from educators and practitioners because of its direct impact on academic success and achievement. Engaged students tend to perform better academically and exhibit fewer undesirable study behaviors, thereby enhancing academic outcomes.

OBJECTIVE: This systematic literature review consolidates research on the impact of perceived teacher support on student engagement in higher education. This study emphasizes the association between teacher support in improving students’ academic performance, motivation, and retention. Furthermore, the review explores key theoretical frameworks, such as self-determination theory and social cognitive theory, alongside methodological tools such as measurement instruments and statistical analyses. The goal is to equip psychologists and educational researchers with insights into the relevant frameworks, tools, and methods for advancing future studies within the context of higher education.

METHODS: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology. We conducted a comprehensive search for academic studies published in English within databases such as APA PsycNet, Scopus, ERIC, EBSCOHost, ProQuest, and PubMed to identify eligible studies published between 2014 and 2024.

RESULTS: A review of 13 selected articles revealed that both students’ personal characteristics and school environment factors mediate and moderate the relationship between perceived teacher support and student engagement. The students’ personal characteristics factors include self-efficacy, the fulfillment of psychological needs, and motivation, whereas school environment factors involve the learning environment and the quality of teacher-student and peer relationships. Our findings show a lack of studies prior to 2020, with most research conducted in China and limited contributions from Malaysia and Vietnam. The reviewed articles predominantly used cross-sectional quantitative designs and self-report questionnaires, employing statistical methods like path analysis and structural equation modeling. Theoretical frameworks on student engagement mostly followed Fredricks et al.’s model, while teacher support theories varied, with three main patterns identified: direct influence, mediation through basic psychological needs, and social cognitive perspectives. This review emphasizes the crucial role of teacher support in enhancing student engagement in higher education and urges further exploration in this under-researched area.

CONCLUSION: In conclusion, this review underscores the significant role of teacher support in enhancing student engagement in higher education. It highlights key theoretical frameworks and research methodologies, offering valuable insights for future studies aimed at advancing teacher support and student engagement in this context.

PMID:39934874 | DOI:10.1186/s40359-025-02412-w

Stem Cell Res Ther. 2025 Feb 11;16(1):65. doi: 10.1186/s13287-025-04184-x.

ABSTRACT

OBJECTIVE: This study aims to assess the effectiveness and safety of mesenchymal stem cell (MSC) transplantation in the treatment of autoimmune and rheumatic immune diseases through randomized controlled trials (RCTs).

METHODS: Two researchers conducted a comprehensive search of Chinese and English databases from their inception until Dec. 2023. The literature screening and data extraction were then performed. Statistical analysis was carried out using RevMan 5.4 software.

RESULTS: A total of 42 relevant RCTs, involving 2,183 participants, were ultimately included in this study. These RCTs encompassed four types of rheumatic immune and bone diseases, namely rheumatoid arthritis (RA), osteoarthritis (OA), spondyloarthritis, systemic sclerosis arthritis, systemic lupus erythematosus (SLE), inflammatory bowel disease, multiple sclerosis, primary Sjögren’s syndrome (PSS). The systematic review indicates that MSC transplantation may improve spondyloarthritis, RA, PSS. The meta-analysis reveals that MSC transplantation significantly improved symptoms in patients with OA [VAS (visual analogue scale): bone marrow: SMD = – 0.95, 95% CI – 1.55 to – 0.36, P = 0.002; umbilical cord: SMD = – 1.25, 95% CI – 2.04 to – 0.46, P = 0.002; adipose tissue: SMD = -1.26, 95% CI -1.99 to – 0.52, P = 0.0009)], SLE [Systemic lupus erythematosus disease activity index (SLEDAI): SMD = – 2.32, 95% CI – 3.59 to – 1.06, P = 0.0003], inflammatory bowel disease [clinical efficacy: RR = 2.02, 95% CI 1.53 to 2.67, P < 0.00001]. However, MSC transplantation may not improve the symptoms of multiple sclerosis and systemic sclerosis (Ssc). Importantly, MSC transplantation did not increase the incidence of adverse events (OA: RR = 1.23, 95% CI 0.93 to 1.65, P = 0.15; SLE: RR = 0.83, 95% CI 0.28 to 2.51, P = 0.76; Inflammatory bowel disease: RR = 0.99, 95% CI 0.81 to 1.22, P = 0.96; Multiple sclerosis: RR = 1.12, 95% CI 0.81 to 1.53, P = 0.50), supporting its safety profile across the included studies. These findings suggest that MSC transplantation holds promise for several rheumatic and autoimmune diseases while highlighting areas where further research is warranted.

CONCLUSION: MSC transplantation may have the potential to treat autoimmune and rheumatic immune diseases. Moreover. MSC transplantation appears to be relatively safe and could be considered as a viable alternative treatment option for autoimmune and rheumatic immune diseases.

PMID:39934871 | DOI:10.1186/s13287-025-04184-x

Immun Ageing. 2025 Feb 11;22(1):6. doi: 10.1186/s12979-025-00500-4.

ABSTRACT

BACKGROUND: The relationship between psoriasis and aging remains unclear. Biological age is considered as a tool for strong association with aging, but there is a lack of reports on the relationship between biological age and psoriasis. Therefore, this study aimed to explore the relationship between biological age and psoriasis.

METHODS: Patients with psoriasis and non-psoriasis were recruited from National Health and Nutrition Examination Survey (NHANES) (12,973 cases), Medical Information Mart for Intensive Care (MIMIC-IV) (558 cases) and The First Clinical Medical College of Zhejiang Chinese Medical University (206 cases). Biological age was calculated using Klemera-Doubal method age (KDM-age) and phenotypic age (PhenoAge). Linear regression and logistic regression were used to explore the association between psoriasis and biological age advance. Cox regression was used to investigate the association between biological age advance and mortality. Finally, biological age advance was used to predict the death of psoriasis patients.

RESULTS: In NHANES, linear regression showed that psoriasis led to a 0.54 advance in PhenoAge (Adjust Beta: 0.54, 95CI: 0.12-0.97, p = 0.018). The KDM-age advance due to psoriasis was not statistically significant (p = 0.754). Using data from China, we came to the new conclusion that for every unit rise in Psoriasis Area and Severity Index, PhenoAge advance rose by 0.12 (Beta: 0.12, 95CI: 0.01-0.22, p = 0.031). Using NHANES data, cox regression shows for every unit rise in PhenoAge advance patients had an 8% rise in mortality (Adjust hazard ratio: 1.08, 95CI: 1.04-1.12, p < 0.001). Using MIMIC-IV, logistic regression showed a 13% increase in mortality within 28 days of admission for every 1 unit rise in PhenoAge advance (odds ratio: 1.13, 95CI: 1.09-1.18, P < 0.001). Finally, we used PhenoAge advance to predict death, with an AUC of 0.71 in the NHANES, an ACU of 0.79 for predicting death within 1 years in the general ward of MIMIC-IV. In the ICU of MIMIC-IV, the AUC for predicting death within 28 days was 0.71.

CONCLUSION: Psoriasis leads to accelerated biological aging in patients, which is associated with the severity of psoriasis and more comorbidities. In addition, PhenoAge has the potential to monitor the health status of patients with psoriasis.

PMID:39934868 | DOI:10.1186/s12979-025-00500-4

Reprod Health. 2025 Feb 12;22(1):21. doi: 10.1186/s12978-025-01964-9.

ABSTRACT

BACKGROUND: One of the most serious problems that threatens the sexual health of couples is diabetes. Diabetes is a global public health crisis affecting more than 0.5 billion adults worldwide. Inefficiency in implementing family planning or childbearing, sexually transmitted infections and sexual disorders in these patients can lead to psychological problems such as feelings of inadequacy, despair, loss of self-esteem and psychological consequences. Action research has the dual purpose of action, to bring about change in society or an organization or program, and research to increase the understanding of the researcher or the people involved with the problem, or both, in the wider community. Therefore, this study was designed with the aim of improving the sexual health of couples with diabetes with an action research approach.

METHODS: This study will be done with an action research approach in four phases and several steps. In the first phase (planning), which includes 4 steps, during which the needs and challenges of sexual health of couples with diabetes are explained ([with a qualitative and quantitative approach), the literature review of databases, the explanation of suitable and practical solutions, the prioritization of strategy improve sexual health Diabetic couples and development of sexual health promotion program for diabetic couples and Identifying sexual function and sexual satisfaction before implementing the program [before action]will be done. In the second phase (action), the program resulting from the first phase will be implemented, and in the third and fourth phases, the program will be continuously observed and reflected in order to adjust and improve the program. Qualitative data analysis using conventional content analysis method, quantitative data analysis will be done with SPSS 27 statistical software.

CONCLUSION: Since diabetes affects the sexual health and marital satisfaction of couples, and considering that providing sexual health is one of the duties of reproductive health practitioners, and considering that the study of strategic action research is accepted to change attitudes, behavior and performance in the system. It seems that the application of the technical action research method opens the field for the entry of a research team consisting of various relevant experts to implement the plan resulting from It is the participants’ own needs and strategy open.

PMID:39934859 | DOI:10.1186/s12978-025-01964-9

Arthritis Res Ther. 2025 Feb 11;27(1):30. doi: 10.1186/s13075-025-03499-7.

ABSTRACT

BACKGROUND: There is a substantial need for ex vivo cartilage damage models to assess new emerging cartilage repair strategies. Ex vivo cartilage explant models have the advantages of achieving standardized and reproducible experimental conditions while maintaining the cells in their native tissue environment. This study aimed to establish a bovine cartilage damage model to evaluate the safety and efficacy of novel cartilage repair therapies. We hypothesized that combining transient exposure to matrix-degrading enzymes with mechanical loading on bovine cartilage would simulate cartilage damage.

METHODS: Prior to mechanical load, bovine osteochondral plugs underwent a brief 5-minutes treatment with collagenase to induce mild cartilage damage by disrupting the collagen network. To induce a moderate cartilage damage, aggrecanase 1 and aggrecanase 2 were additionally applied to the cartilage for 40 min post-collagenase treatment to degrade aggrecan. Data was analyzed using ANOVA or the Friedman test.

RESULTS: Observations revealed a statistically significant loss of sulphated glycosaminoglycan (sGAG) using both Collagenase Treatment (CT) and Collagenase and Aggrecanase Treatment (CAT), while chondrocytes viability was maintained. Both treatments resulted in a significantly elevated release of inflammation markers during the initial two days, including IL6 and nitric oxide. Collagenase treatment also significantly increased neo-epitopes of aggrecan compared to the untreated plugs at day 7, suggesting endogenous aggrecanase activation upon collagen network disruption. The additional effect of mechanical loading on cartilage degeneration was also explored in the CT group. Mildly damaged cartilage treated solely with collagenase could withstand 1 h per day of cyclical load, at 10-20% compression of cartilage thickness combined with interfacial shear at 25 degrees. However, higher compression levels (20-40% of cartilage thickness) with the same shear stress regimen led to a significant increase in surface chondrocyte death, with no evidence of TUNEL staining.

CONCLUSIONS: This study establishes a promising model for evaluating cartilage repair strategies, and screening anti-catabolic drugs, particularly overload-related cartilage damage.

PMID:39934857 | DOI:10.1186/s13075-025-03499-7