Tag: pubmed

Eur J Dent Educ. 2022 Jul 13. doi: 10.1111/eje.12836. Online ahead of print.

ABSTRACT

INTRODUCTION: Providing undergraduate dental students with a range of clinical experiences in fixed prosthodontics procedures is an important component of dental education. The aim of this retrospective study was to analyse the types of laboratory-fabricated fixed prosthodontics clinical units completed by undergraduate students over 10 consecutive years and determine any significant trends.

MATERIALS AND METHODS: The fixed prosthodontics treatment registers from 2012 to 2021 were reviewed and the different types of completed fixed prosthodontics units and total number of fixed prosthodontics units were recorded for each year. Completed units were categorised according to the type of restoration and expressed in whole numbers and as a percentage of the total number of units completed in each year. The data was presented in table and graph form. Mann-Kendall tests were performed to statistically analyse for trends in the different restoration types.

RESULTS: Throughout all study years, porcelain bonded to metal (PBM) crowns (48.25%, range 35.70% – 59.91%) were the most frequently completed fixed prosthodontics unit followed by full gold crowns (FGC) (20.84%, range 14.89% – 27.30%) and all-ceramic crowns (ACC) (12.70%, range 3.67% – 24.41%). Collectively, PBM, FGC and ACC comprised 81.80% of all completed fixed prosthodontics units. There were observed trends of increased use of all types of all-ceramic containing restorations, all types of all-gold containing restorations, all types of partial coverage restorations and specifically ceramic onlays and gold onlays. There were observed trends of reduced use of cast gold post-cores and all types of bridges.

CONCLUSION: PBM crowns were the mainstay laboratory-fabricated fixed prosthodontic unit completed over 10 years of undergraduate student fixed prosthodontics clinical practice.

PMID:35822395 | DOI:10.1111/eje.12836

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Jul;36(7):540-544;558. doi: 10.13201/j.issn.2096-7993.2022.07.012.

ABSTRACT

Objective:To investigate the effect of transoral endoscopic thyroid surgery in the central lymph node dissection of thyroid cancer. Methods:Twenty patients underwent endoscopic thyroidectomy via oral vestibular approach （TOETVA group） and 20 gender and age matched patients underwent conventional open thyroidectomy were selected in this study. The clinical data, number of lymph node dissection and postoperative complications of the two groups were collected and analyzed. SPSS 24.0 statistical software was used for data analysis. Results:There was no significant differences in age, BMI, tumor size or the number of Hashimoto’s thyroiditis patients between the TOETVA group and the open group（P>0.05）. The operation time（[117.30±10.54]min） and postoperative drainage volume（[146.05±30.66]mL） in the TOETVA group were significantly higher than those in the open group（[59.05±6.40]min, [77.90±22.18]mL）, P<0.001. The pain in the open group 24 h after surgery was more severe than that in the TOETVA group（P<0.05）. The total number of central lymph nodes, the number of pre-laryngeal lymph nodes and the number of pre-tracheal lymph nodes cleared by the two groups were similar, and the number of final positive lymph nodes had no significant difference. However, the number of paratracheal lymph nodes removed in the TOETVA group was more（7.8±4.2） nodes than that in the open group（6.4±3.9） nodes, P<0.05. There was no significant difference in postoperative complications between the two groups. The scores of cosmetic evaluation and rating of cicatrices in the TOETVA group six months after surgery were（0.77±0.58） significantly lower than those in the open group（4.30±1.54）, P<0.001. Conclusion:In central lymph node dissection, the efficiency of TOETVA is similar to that of traditional open thyroid surgery. For special anatomical regions, endoscopic surgery is more efficient. At the same time, TOETVA does not increase the incidence of related complications, and has good cosmetic effect.

PMID:35822383 | DOI:10.13201/j.issn.2096-7993.2022.07.012

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Jul;36(7):515-519. doi: 10.13201/j.issn.2096-7993.2022.07.007.

ABSTRACT

Objective:To investigate the characteristics of habitual sleeping position and triggered movement in patients with benign paroxysmal positional vertigo（BPPV）. Methods:The patients with idiopathic tubulitic BPPV who the symptoms were relieved after repositioning were enrolled in this study. The relationship between the side, the tube of otolith detachment and habitual sleeping position and triggered movement was analyzed. Results:①Among the 446 patients, female gender predominated（319 cases, 71.5%）, 41-60 years old group accounted for the highest proportion（192 cases, 43.0%）, and posterior semicircular canal patients accounted for the highest proportion（289 cases, 64.8%）; ②The affected side was associated with habitual sleep postion（P<0.05, ES=0.392）, ipsilateral ear was more common in left or right decubitus; ③There were statistically significant differences in the triggered movement in different types of BPPV（P<0.05, ES=0.380）, BPPV of multiple semicircular canals. Horizontal semicircular canals and posterior semicircular canals were more likely to induce vertigo and nystagmus. Conclusion:Habitual sleeping position and triggered movement could be collected during the diagnosis of BPPV, to predict the affected side and tube. The combination of Roll test and Dix-Hallpike test is more conducive to accurately distinguish the location of otolith shedding.

PMID:35822378 | DOI:10.13201/j.issn.2096-7993.2022.07.007

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Jun;36(6):467-472. doi: 10.13201/j.issn.2096-7993.2022.06.012.

ABSTRACT

Objective:To analyzed allergens and screen for common airborne allergens in patients with allergic rhinitis （AR） in Shenzhen, and identified the distribution pattern of allergens in this region. We aimed to provide scientific and feasible statistical and clinical basis for prevention and treatment of allergenic rhinitis. Methods:For 3351 suspected cases of allergenic rhinitis, 18 kinds of airborne allergen serum-specific IgE were determined using a detection system of BioSciTec GmbH company, and statistical analysis was carried out according to sex, age, severity and seasonal allergen. Results:A total of 3,351 cases with allergic rhinitis were positive for airborne allergens. The top five inhalation allergens were Blomia tropicalis （2231, 66.6%）, Dermatophagoides pterronyssinus （2212, 66.0%）, Dermatophagoides farinae （1986, 59.3%）, Cockroach （967, 28.9%）, and Short ragweed （844, 25.2%）. For the severity of the allergen, Dermatophagoides pterronyssinus ≥ level 3 accounted for 41.3% （1385/3351 cases） and Dermatophagoides farinae ≥level 3 accounted for 40.6% （1360/3351 cases）. Blomia tropicalis were classified as level 2, and other allergens were mainly classified as level 1 or 2. The detection rate among different age groups and gender is significantly different. Conclusion:The main airborne allergens in Shenzhen were Blomia tropicalis, Dermatophagoides pterronyssinus, Dermatophagoides farinae, Cockroach, as well as Short ragweed. The distribution of allergens was affected by sex, age and season.

PMID:35822367 | DOI:10.13201/j.issn.2096-7993.2022.06.012

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Jun;36(6):447-452. doi: 10.13201/j.issn.2096-7993.2022.06.008.

ABSTRACT

Objective:To explore the diagnostic value of American Society of Radiology Thyroid Imaging Reporting and Data System（ACR-TIRADS） and Chinese Thyroid Nodule Ultrasound Malignant Risk Stratification（C-TIRADS） in nodular Hashimoto thyroiditis and papillary thyroid carcinoma with Hashimoto thyroiditis. Methods:This retrospective analysis included 144 patients（204 thyroid nodules） accompanied by nodular Hashimoto thyroiditis or papillary thyroid carcinoma under the background of Hashimoto thyroiditis confirmed by surgical pathology examination in the First Affiliated Hospital of Hebei North University from August 2018 to May 2021, all nodules were examined by ultrasound, and 204 nodules were scored and graded according to the classification standards of ACR-TIRADS and C-TIRADS. The surgical pathological results were the gold standard. The receiver operating characteristic curve of ACR-TIRADS and C-TIRADS was constructed to evaluate and compare the diagnostic performance of the two guideline. Results:①Ultrasound feature results showed that nodular Hashimoto thyroiditis and Papillary thyroid carcinoma had statistically significant differences in the location, echogenicity, calcifications and margins（P<0.001）, but there is no significant difference in structure and aspect ratio between the two kinds of nodular（P=0.141, P=0.240）; nodular Hashimoto thyroiditis were mostly absent focal echogenicity and hyperechogenicity, while papillary thyroid carcinoma was mostly manifested as focal echogenicity and extrinsic thyroid invasion. ②The sensitivity and negative predictive value of C-TIRADS were 91.7% and 83.1%, respectively, which were higher than those of ACR-TIRADS, and the difference was statistically significant（P=0.021, P=0.013）; The specificity and positive predictive value of C-TIRADS T were 98.3% and 99.2%, both of which were slightly higher than ACR-TIRADS, althought the difference was not statistically significant（P=0.157, P=0.062）. The area under the curve of the ACR-TIRADS and C-TIRADS were 0.806 and 0.941, respectively, and the difference was statistically significant（P=0.031）. ③The unnecessary FNAB rate of C-TIRADS was 10.3%, which was lower than ACR-TIRADS. Conclusion:C-TI-RADS has a better diagnostic value of nodular Hashimoto thyroiditis and thyroid papillary carcinoma under the background of Hashimoto thyroiditis, which is helpful for clinical evaluation of such nodules.

PMID:35822363 | DOI:10.13201/j.issn.2096-7993.2022.06.008

J Surg Orthop Adv. 2022 Summer;31(2):119-122.

ABSTRACT

Proximal humerus fractures represent one of the most common fractures in the elderly, and are increasingly treated with surgical fixation. Suture augmentation attaching the rotator cuff to the plate has been advocated to combat varus collapse and other associated complications. The objective of this study was to evaluate the contribution of rotator cuff augmentation to stability of proximal humerus fracture fixation. Twelve shoulder specimens from six cadavers underwent simulated two-part and three-part proximal humerus fractures. Matched specimens from the same cadaver were randomized to suture augmentation with locking plate fixation vs. locking plate fixation alone. Greater tuberosity fragment displacement was recorded during cyclic rotational strain of the glenohumeral joint. Greater tuberosity displacement in the two-part fracture model trended towards greater motion without suture augmentation, but did not reach statistical significance (0.032 + 0.012 mm vs. 0.213 + 0.109 mm, p = 0.130). In the three-part fracture model, there was a statistically significant decrease in fracture displacement in the presence of suture augmentation (0.068 + 0.025 mm vs. 2.392 + 0.373 mm, p < 0.001). No specimens demonstrated premature failure during cyclic loading. Suture augmentation of locking plate fixation of three-part proximal humerus fractures results in decreased fracture displacement than locked plating alone, during rotational stresses simulating in vivo rotator cuff deformation forces. (Journal of Surgical Orthopaedic Advances 31(2):119-122, 2022).

PMID:35820099

J Surg Orthop Adv. 2022 Summer;31(2):104-108.

ABSTRACT

Proximal humerus fractures (PHF) are common in elderly and osteoporotic patients, and these fractures are often described using the Neer classification. As reverse shoulder arthroplasty (RSA) for PHF becomes more common, it is helpful to identify the utility of Neer classification in predicting postoperative outcomes for patients undergoing RSA. The medical records of patients undergoing primary RSA for PHF at a single academic institution from 2013-2019 were identified using medical billing codes. A multivariable logistic regression analysis identified independent factors associated with all cause 90-day readmissions, reoperation, and length of stay (LOS) greater than three days. Fifty-five patients (average age of 72.3 ± 8.6 years) were included. No statistically significant differences among two-, three-, and four-part fractures with regard to LOS, discharge location, 90-day readmission, revision surgery, postoperative dislocation, or deep infection were detected. These findings suggest that Neer classification for PHF is not predictive of short-term complications after RSA. (Journal of Surgical Orthopaedic Advances 31(2):104-108, 2022).

PMID:35820096

Hum Vaccin Immunother. 2022 Jul 12:2094641. doi: 10.1080/21645515.2022.2094641. Online ahead of print.

ABSTRACT

Varicella is a contagious disease of children. Qingdao administrated free one-dose and free two-dose universal varicella vaccination schedules in 2013 and 2016 for preschool children. The effectiveness of the vaccination was analyzed in this study. Monthly varicella incidence data of 1-6 years old children during 2007-2020 were obtained from the Qingdao Infectious Disease Reporting Information Management System. We applied Interrupted time series and segmented regression analyses to assess changes in varicella incidence at the beginning of each month and average monthly changes during the vaccination. The vaccination was associated with a reduction of 32.7% in varicella morbidity on average during the 8-year intervention, there is a statistically significant difference between the voluntary period and free vaccination period (χ² = 290.80,P < 0.001). Immediately after the free one-dose vaccination implementation in 2013 and free two-dose vaccination implementation in 2016, varicella incidence decreased by 0.135 cases per 100 000 population (P < 0.001) and increased by 1.189 cases per 100 000 population (P = 0.039), respectively, the results were statistically significant. There were significant declining trends in varicella incidence after free vaccination: 0.135(P < 0.001) and 0.055 (P = 0.025) per month in 2013.7-2016.6 and 2016.7-2020.12, respectively. This study shows a further decaying trend of varicella incidence based on the impact of free two-dose vaccination. It is necessary to prolong free two-dose universal varicella vaccination to strengthen the immune barrier of preschool children sequentially.

PMID:35820088 | DOI:10.1080/21645515.2022.2094641

Alzheimers Dement. 2022 Jul 12. doi: 10.1002/alz.12697. Online ahead of print.

ABSTRACT

INTRODUCTION: This report details the approach taken to providing a dataset allowing for analyses on the performance of recently developed assays of amyloid beta (Aβ) peptides in plasma and the extent to which they improve the prediction of amyloid positivity.

METHODS: Alzheimer’s Disease Neuroimaging Initiative plasma samples with corresponding amyloid positron emission tomography (PET) data were run on six plasma Aβ assays. Statistical tests were performed to determine whether the plasma Aβ measures significantly improved the area under the receiver operating characteristic curve for predicting amyloid PET status compared to age and apolipoprotein E (APOE) genotype.

RESULTS: The age and APOE genotype model predicted amyloid status with an area under the curve (AUC) of 0.75. Three assays improved AUCs to 0.81, 0.81, and 0.84 (P < .05, uncorrected for multiple comparisons).

DISCUSSION: Measurement of Aβ in plasma contributes to addressing the amyloid component of the ATN (amyloid/tau/neurodegeneration) framework and could be a first step before or in place of a PET or cerebrospinal fluid screening study.

HIGHLIGHTS: The Foundation of the National Institutes of Health Biomarkers Consortium evaluated six plasma amyloid beta (Aβ) assays using Alzheimer’s Disease Neuroimaging Initiative samples. Three assays improved prediction of amyloid status over age and apolipoprotein E (APOE) genotype. Plasma Aβ42/40 predicted amyloid positron emission tomography status better than Aβ42 or Aβ40 alone.

PMID:35820077 | DOI:10.1002/alz.12697

JMIR Res Protoc. 2022 Jul 11. doi: 10.2196/35760. Online ahead of print.

ABSTRACT

BACKGROUND: Individuals diagnosed with COVID-19 are instructed to self-isolate at home. However, during self-isolation, they may experience anxiety and insufficient care. Patient portals can allow patients to self-monitor and share their health status with healthcare professionals for remote follow-up, but little data is available on the feasibility of their use.

OBJECTIVE: This manuscript presents the protocol of the Opal-COVID Study which has four objectives: 1) assess the implementation of using the Opal patient portal for distance monitoring of COVID-19 patients self-isolating at home; 2) identify influences on the intervention’s implementation; and describe 3) service and 4) patient outcomes of this intervention.

METHODS: This mixed-method pilot study aims to recruit 50 COVID-19 patient participants tested at the McGill University Health Centre (Montreal, Canada) for 14 days of remote follow-up. With access through a smartphone app to an existing patient portal configured for this study, patients will complete a daily self-assessment of symptoms, vital signs, and mental health, monitored by a nurse, and receive teleconsultations, as needed. Study questionnaires will be administered to collect data on sociodemographic characteristics, medical background, implementation outcomes (acceptability, usability, and respondent burden) and patient satisfaction. Coordinator logbook entries will inform on feasibility outcomes, namely, recruitment/retention rates and fidelity, as well as on the frequency and nature of contacts with healthcare professionals via Opal. The statistical analyses for Objectives 1 (implementation outcomes), 3 (service outcomes), and 4 (patient outcomes) will evaluate the effects of time and sociodemographic characteristics on the outcomes. For Objectives 1 (implementation outcomes) and 4 (patient outcomes), the statistical analyses will also examine the attainment of predefined success thresholds. As to the qualitative analyses, for Objective 2 (influences on implementation), semi-structured qualitative interviews will be conducted with four groups of stakeholders (i.e., patient participants, healthcare professionals, technology developers and study administrators) and submitted to content analysis, guided by the Consolidated Framework for Implementation Research to help identify barriers and facilitators of implementation. For Objective 3 (service outcomes), reasons for contacting healthcare professionals through Opal will also be submitted to content analysis.

RESULTS: Between December 2020 and March 2021, 51 patient-participants were recruited. Qualitative interviews were conducted with 39 involved stakeholders, from April to September 2021. Delays were experienced due to measures taken at the MUHC to address COVID-19. The quantitative and qualitative analyses began in May 2022. As of June 2022, two manuscripts (respectively on the implementation and the patient outcomes) were being prepared and three conference presentations had been given on the study’s methods.

CONCLUSIONS: This protocol is designed to generate multidisciplinary knowledge on the implementation of a patient portal-based COVID-19 care intervention and will lead to a comprehensive understanding of feasibility, stakeholder experience, and influences on implementation that may prove useful for scaling up similar interventions.

CLINICALTRIAL: ClinicalTrials.gov identifier NCT04978233.

INTERNATIONAL REGISTERED REPORT: DERR1-10.2196/35760.

PMID:35820054 | DOI:10.2196/35760