Tag: pubmed

J Coll Physicians Surg Pak. 2026 Feb;36(2):233-239. doi: 10.29271/jcpsp.2026.02.233.

ABSTRACT

This meta-analysis aimed to compare the efficacy and safety of Diode laser haemorrhoidoplasty (DLH) with conventional haemorrhoidectomy (CH) techniques, namely Milligan-Morgan haemorrhoidectomy (MMH) and Ferguson haemorrhoidectomy (FH), for the treatment of symptomatic haemorrhoids. A search of PubMed, Embase, Cochrane, Web of Science, and Scopus identified 13 eligible studies. Primary outcomes included intraoperative blood loss, postoperative bleeding, pain (measured by VAS), complications (e.g., urinary retention and anal stenosis), recovery time, and recurrence rate. Statistical analysis used both random-effects and fixed-effects models, with results reported as 95% confidence intervals (CIs), and heterogeneity was assessed using the I2 statistic. The results showed that DLH offered significant benefits over MMH and FH, including reduced intraoperative blood loss (MD = -20.19 mL, 95% CI: -28.32 -12.07; p <0.001), lower postoperative bleeding (OR = 0.32, 95% CI: 0.11 – 0.93; p = 0.04), and less postoperative pain, both immediately and one week later. Key Words: Diode laser haemorrhoidoplasty, Milligan-Morgan haemorrhoidectomy, Ferguson haemorrhoidectomy, Haemorrhoids, Meta-analysis.

PMID:41689325 | DOI:10.29271/jcpsp.2026.02.233

J Coll Physicians Surg Pak. 2026 Feb;36(2):217-222. doi: 10.29271/jcpsp.2026.02.217.

ABSTRACT

OBJECTIVE: To compare serum homocysteine, zinc, and copper levels between chronic obstructive pulmonary disease (COPD) patients and healthy controls, and to assess their associations with systemic inflammation.

STUDY DESIGN: A comparative cross-sectional study. Place and Duration of the Study: Department of Pulmonary Diseases, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkiye, from February to April 2025.

METHODOLOGY: This study evaluated homocysteine, folic acid, vitamin B12, zinc, and copper levels in 30 COPD patients and 30 healthy controls (HCs). Pearson’s chi-square test was used to compare categorical variables between groups. The Student’s t-test was employed for comparisons between two groups. Pearson’s correlation analysis was conducted to assess the relationship between continuous variables.

RESULTS: Statistically significant differences were found in leucocyte, platelet, red cell distribution width (RDW), immature granulocyte, and immature granulocyte percentage levels in COPD patients (p <0.001, p = 0.024, p = 0.002, p = 0.035, and p = 0.022, respectively). CRP levels were significantly elevated in the COPD group (p = 0.006). No statistically significant differences were found in homocysteine, folic acid, vitamin B12, zinc, and copper levels between the COPD and Control groups (p >0.05). All measured values in both groups were within the normal reference ranges. However, zinc levels positively correlated with RDW (r = 0.417; p = 0.030), and a negative correlation was observed between copper levels and RDW (r = -0.543; p = 0.009) in the COPD group.

CONCLUSION: Homocysteine, zinc, copper, vitamin B12, and folic acid levels did not differ between COPD patients and HCs, all within normal ranges. Secondary analyses showed significant haematogram and CRP alterations, indicating systemic inflammation. These markers cannot be used as inflammatory parameters in COPD.

KEY WORDS: COPD, Homocysteine, Zinc, Copper, Vitamin B12, Folic acid.

PMID:41689323 | DOI:10.29271/jcpsp.2026.02.217

Forensic Sci Int Genet. 2026 Feb 3;83:103444. doi: 10.1016/j.fsigen.2026.103444. Online ahead of print.

ABSTRACT

Mitochondrial DNA (mtDNA) analysis is a frequently used tool for determining the potential origin of biological traces found at crime scenes. The method typically involves comparing the genetic profile of the trace with that of a suspect. While a mismatch between the two profiles usually leads to the exclusion of the suspect, the evidential value of a match is sometimes difficult to grasp. This is particularly true in cases that are more complex than a simple trace-suspect comparison. We considered two such scenarios and developed means for appropriate statistical interpretation of the respective mtDNA results. One scenario requires the evaluation of a composite hypothesis about trace donorship in multiple cases involving an mtDNA profile match with one and the same suspect. The other scenario calls for the consideration of a second mtDNA profile found at the crime scene that matches a matrilineally unrelated contact person of the suspect. For both scenarios, we propose formally linked mathematical methods for interpreting the mtDNA data which, under certain assumptions, allow valid quantification of the evidential value of the latter for or against the suspect. Furthermore, we illustrate the application of both methods with example calculations under realistic assumptions about the required parameters.

PMID:41687183 | DOI:10.1016/j.fsigen.2026.103444

ESMO Open. 2026 Feb 12;11(3):106043. doi: 10.1016/j.esmoop.2025.106043. Online ahead of print.

ABSTRACT

BACKGROUND: The phase III NAPOLI 3 trial established liposomal irinotecan in combination with 5-fluorouracil/leucovorin plus oxaliplatin (NALIRIFOX) as a superior first-line (1L) treatment option compared with gemcitabine plus nab-paclitaxel (Gem + NabP) in patients with previously untreated metastatic pancreatic ductal adenocarcinoma (mPDAC), without imposing an upper age limit on enrollment. The current analysis of the NAPOLI 3 data investigated the potential impact of older age on the efficacy and safety of NALIRIFOX.

PATIENTS AND METHODS: Adults with previously untreated mPDAC were randomly assigned in a 1 : 1 ratio to receive NALIRIFOX or Gem + NabP. This post hoc analysis compared outcomes for patients aged ≥70 years versus <70 years. Endpoints included overall survival (OS), progression-free survival (PFS), and safety. No statistical comparison was carried out.

RESULTS: Of the 770 patients in the NAPOLI 3 population, 553 were aged <70 years and 217 were aged ≥70 years. Median OS and median PFS with NALIRIFOX were 11.7 months and 7.4 months, respectively, in the <70 years subgroup (n = 275) and 10.0 months and 7.3 months, respectively, in the ≥70 years subgroup (n = 108). The benefit of NALIRIFOX versus Gem + NabP was preserved in the older versus younger subgroup. There was no evidence of increased treatment-related toxicity in the older (versus younger) subgroup.

CONCLUSIONS: NALIRIFOX improved mPDAC survival versus Gem + NabP irrespective of patient age, with no signals for reduced tolerability in the older (versus younger) patients. The results provide reassurance that triplet therapy with NALIRIFOX is an efficacious and tolerable regimen in older treatment-naive patients with mPDAC who were fit enough for inclusion in NAPOLI 3, supporting consideration of its use as 1L therapy in this population.

PMID:41687160 | DOI:10.1016/j.esmoop.2025.106043

Sci Total Environ. 2026 Feb 12;1019:181520. doi: 10.1016/j.scitotenv.2026.181520. Online ahead of print.

ABSTRACT

Previously reported rooftop ambient aerosol measurements in Raleigh, NC, USA, detected episodic events where sub-10 nm particle number concentrations (PNC) exceeded 3.73 × 10⁵ cm^-3. Their small size and temporally stable modal diameter (sometimes persisting for days) indicated origins from nearby primary emission sources rather than mesoscale new particle formation (NPF) events. To investigate potential sources, simulations were conducted using the U.S. Environmental Protection Agency’s Gaussian plume-based model, AERMOD. Campus surveys and Google Earth analyses identified three candidate sources near the measurement site, including two combined heat and power (CHP) facilities with high-efficiency natural gas turbines and heat recovery steam generators that provide energy to NC State’s campus. Distinct point sources were modeled for each facility using an emission factor of 5 × 10^-4 g s^-1. The study explored source contributions under varying micrometeorological conditions (e.g., wind speed, wind direction, solar radiation, and planetary boundary layer height). Wind pattern analysis revealed distinct plumes from individual power plants reaching the receptor site. Statistical analyses confirmed wind direction and speed as the strongest predictors of modeled mass concentrations, and that observed PNC profiles during NPF and particle burst events are fundamentally distinct. Exceptionally high sub-10 nm particle growth rates were observed during plume transport, averaging 104-120 nm hr^-1. These findings reveal that expanding deployment of CHPs for distributed power generation may pose unrecognized health risks through sub-10 nm particle emissions with demonstrated respiratory and neurological impacts. New emission standards may be needed to address ultrafine particle production from natural gas combustion technologies.

PMID:41687154 | DOI:10.1016/j.scitotenv.2026.181520

Int J Drug Policy. 2026 Feb 12;150:105183. doi: 10.1016/j.drugpo.2026.105183. Online ahead of print.

ABSTRACT

Systemic violence is a structural feature of drug economies and a key spillover of prohibitionist drug policies. Despite its centrality, the concept is often applied in ways that obscure its distinct purposes, market levels, and organizational contexts. To address this gap, the study examines violence at the intersection of mafia activity and drug markets, focusing on its distribution across market levels (retail, national wholesale, transnational), organizational functions (governance and trade), and rivalry configurations (inter-, intra-, and extra-clan). It draws on a press-based dataset of mafia-related homicides in Italy (2014-2024) to code and analyze these dynamics. Results show that more than half of all mafia homicides are drug-related, mainly tied to governance activities and concentrated at the retail level of the market. This pattern marks a qualitative shift in mafia violence: increasingly selective, embedded in market dynamics, confined to criminal circuits. Statistical analyses reveal significant associations between activity type, market level, and rivalry configuration, indicating that coercion concentrates where regulatory control and market participation intersect. This pattern underscores the multifunctional nature of Italian mafias, which govern markets from within while actively engaging in trade. By grounding this overlap empirically, the study advances theoretical debates on organized crime’s role in shaping illicit economies. It also offers a replicable framework for analyzing drug-related violence in the absence of official statistics.

PMID:41687149 | DOI:10.1016/j.drugpo.2026.105183

J Surg Res. 2026 Feb 12;319:141-151. doi: 10.1016/j.jss.2026.01.012. Online ahead of print.

ABSTRACT

INTRODUCTION: Preoperative abnormal sodium level is suggested to increase mortality risk in surgeries, including colectomy for colorectal cancer. However, it remains unclear which age groups are most affected by this electrolyte derangement. To bridge this gap and to better risk stratify patients preoperatively, we assessed the association of age on patients with abnormal sodium level undergoing colectomy for colorectal cancer.

MATERIALS AND METHODS: We reviewed the American College of Surgeons National Safety Quality Improvement Program Procedure-Targeted Colectomy database from 2015-2020, identifying patients over the age of 18 who underwent colectomy for primary colon cancer. We dichotomized the group by age, either younger than or 65 y and older. We collected demographics, comorbidities, laboratory values, and operative variables. We performed descriptive statistics, univariate analysis, and multivariable logistic regression with interaction term analysis. Our primary outcome was the relationship between age and 30-d mortality among patients with abnormal sodium levels. We defined statistical significance using two-sided tests as P < 0.05.

RESULTS: We identified 89,745 patients who underwent colectomy for primary colon cancer, 50,528 of those were aged 65 y and older. On multivariate analysis, we found that age ≥65 y is associated with an increased risk of mortality (odds ratio [OR], 2.574, P < 0.01). We found sodium level to have a U-shaped relationship with increased risk of mortality for both hyponatremia and hypernatremia (hyponatremia OR, 1.38, P < 0.01, hypernatremia OR, 1.878, P < 0.01), controlling for demographics and comorbidities. On multivariate interaction analysis, sodium level did not pose a clinically significant higher mortality risk to patients’ age (OR, 1.002, P < 0.01).

CONCLUSIONS: Advanced age and abnormal sodium level are independently associated with 30-d mortality following colectomy for colon cancer. Furthermore, the association between abnormal sodium levels and mortality does not differ in a clinically meaningful way between younger and older patients. This finding reinforces that abnormal sodium level is associated with an increased mortality risk after colectomy for colon cancer and provides a potential target for further study.

PMID:41687140 | DOI:10.1016/j.jss.2026.01.012

Retina. 2026 Feb 3. doi: 10.1097/IAE.0000000000004800. Online ahead of print.

ABSTRACT

PURPOSE: To evaluate the relationship between sleep disorders, including insomnia and obstructive sleep apnea (OSA), personal chronotype, and age-related macular degeneration (AMD).

METHODS: We systematically reviewed articles in PubMed, EMBASE, and Web of Science that provided information on AMD and sleep disorders, whether qualitative or quantitative. We systematically screened the abstracts of potentially eligible studies and subsequently assessed the full-text reports of those deemed relevant in detail. The study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

RESULTS: Twenty-two studies were included in our final review. OSA was associated with a higher risk of AMD, based on seven studies (HR 1.43; 95% CI 1.14-1.79 p < 0.001; I2 = 96%). The analysis showed a statistically significant association between the morning person chronotype and an increased odds of AMD (OR 1.19; 95% CI 1.10-1.30; p < 0.001; I2 = 0%). We found little to no association between sleep duration and insomnia.

CONCLUSION: Our meta-analyses, although based on a limited number of studies, indicate that sleep disorders, particularly OSA, are associated with increased odds of developing AMD. However, further research is needed to understand how sleep duration affects disease progression and to determine the benefits of treating sleep disorders for AMD.

PMID:41687120 | DOI:10.1097/IAE.0000000000004800

Acta Med Port. 2026 Feb 2;39(2):114-124. doi: 10.20344/amp.23502. Epub 2026 Feb 2.

ABSTRACT

INTRODUCTION: Red blood cell (RBC) transfusions are frequent in cardiac surgery and are associated with higher morbidity, mortality, prolonged hospitalization, and increased healthcare costs. Several patient- and procedure-related factors have been identified as transfusion predictors. Studying these predictors in specific populations allows more accurate risk stratification and tailored clinical decision-making. RBC transfusions represent a significant economic burden for healthcare systems due to increased resource utilization and hospital costs overall. The aim of this study was to identify independent risk factors of RBC transfusion, evaluate its economic impact, and estimate potential cost savings from eliminating preoperative anemia.

METHODS: We conducted a retrospective cohort study at a tertiary hospital in Portugal, including 661 adults who underwent elective cardiac surgery between April 2020 and April 2021. The primary outcome was the need for at least one RBC transfusion during hospitalization. Secondary outcomes included 30-day mortality, infection, acute kidney injury, prolonged mechanical ventilation, intensive care unit stay, hospital length of stay (LOS), and hospital costs. Independent risk factors were identified using multivariable logistic regression. An economic analysis compared costs between transfused and non-transfused patients. To estimate potential cost reductions, a simulation model was developed assuming the elimination of preoperative anemia and applying the observed transfusion patterns of non-anemic patients to the entire cohort.

RESULTS: Red blood cell transfusion occurred in 41.3% of patients. The identified predictors were preoperative anemia (OR 3.67; 2.00 – 6.74), female sex (OR 2.06; 1.22 – 3.48), higher EuroSCORE II (OR 1.15; 1.03 – 1.29), longer cardiopulmonary bypass time (OR 1.01; 1.00 – 1.02) and lower intraoperative nadir hemoglobin (OR 0.48; 0.40 – 0.58), after adjusting for postoperative hemorrhage. Transfused patients had longer hospital stays (median 10 vs 8 days) and higher costs (median increase of €2264.44). After adjustment for infection and prolonged ventilation, transfusion was no longer independently associated with LOS. Eliminating preoperative anemia could prevent 47 transfusions, reduce 94 hospital days, and save €106 429 over 13 months overall.

CONCLUSION: Red blood cell transfusion was associated with longer hospital stays, likely due to higher infection rates and prolonged mechanical ventilation. Correcting preoperative anemia could potentially reduce transfusion rates and related hospital costs in cardiac surgery.

PMID:41687115 | DOI:10.20344/amp.23502

Acta Med Port. 2026 Feb 2;39(2):104-113. doi: 10.20344/amp.23847. Epub 2026 Feb 2.

ABSTRACT

INTRODUCTION: Dementia is one of the leading causes of dependency among older people and poses a critical challenge for long-term care systems. Despite the importance of the issue, national data on the prevalence of dementia in residential care homes remain limited.

METHODS: A cross-sectional, observational, and institution-based study was conducted within the framework of the SINDIA project. The study was based on an online survey addressed to the technical directors of residential care homes for older people in Portugal, carried out between January and July 2024. The questionnaire collected information on institutional characteristics (sector, territorial location, base monthly fee, dementia specialization, and total number of residents) and on the prevalence of formally diagnosed dementia cases and of cognitive decline without a recorded diagnosis. Data were analyzed using the R software (version 4.1.2). Mean percentages and 95% confidence intervals (Student’s t-method), weighted by NUTS-2 region, were calculated. A hierarchical cluster analysis (Ward’s method) was also performed to identify distinct institutional profiles.

RESULTS: On average, 31.7% of residents had a formal dementia diagnosis and 22.3% showed signs of undiagnosed cognitive decline, resulting in 50.2% of the resident population presenting some degree of cognitive impairment, after data cleaning. The proportion varied across territories, institutional sectors, monthly fees and self-reported specialization. A cluster analysis identified three distinct institutional profiles, with a majority group of facilities characterized by lower diagnostic formalization, especially in the non-profit sector and among lower-cost institutions.

CONCLUSION: The findings are suggestive of a very high prevalence of cognitive impairment in Portuguese residential care homes. These results highlight the need for public policies aimed at improving early diagnosis, enhancing staff training, and reducing territorial and institutional inequalities in the response to dementia.

PMID:41687112 | DOI:10.20344/amp.23847