Tag: statistics

JMIR Mhealth Uhealth. 2024 Dec 16;12:e63316. doi: 10.2196/63316.

ABSTRACT

BACKGROUND: Obsessive-compulsive disorder (OCD) is the third most prevalent mental health disorder in Singapore, with a high degree of burden and large treatment gaps. Self-guided programs on mobile apps are accessible and affordable interventions, with the potential to address subclinical OCD before symptoms escalate.

OBJECTIVE: This randomized controlled trial aimed to examine the efficacy of a self-guided OCD program on the mobile health (mHealth) app Intellect in improving subclinical OCD and maladaptive perfectionism (MP) as a potential moderator of this predicted relationship.

METHODS: University students (N=225) were randomly assigned to an 8-day, self-guided app program on OCD (intervention group) or cooperation (active control). Self-reported measures were obtained at baseline, after the program, and at a 4-week follow-up. The primary outcome measure was OCD symptom severity (Obsessive Compulsive Inventory-Revised [OCI-R]). Baseline MP was assessed as a potential moderator. Depression, anxiety, and stress (Depression Anxiety and Stress Scales-21) were controlled for during statistical analyses.

RESULTS: The final sample included 192 participants. The intervention group reported significantly lower OCI-R scores compared with the active control group after the intervention (partial eta-squared [η_p²]=0.031; P=.02) and at 4-week follow-up (η_p²=0.021; P=.044). A significant, weak positive correlation was found between MP and OCI-R levels at baseline (r=0.28; P<.001). MP was not found to moderate the relationship between condition and OCI-R scores at postintervention (P=.70) and at 4-week follow-up (P=.88).

CONCLUSIONS: This study provides evidence that the self-guided OCD program on the Intellect app is effective in reducing subclinical OCD among university students in Singapore. Future studies should include longer follow-up durations and study MP as a moderator in a broader spectrum of OCD symptom severity.

TRIAL REGISTRATION: ClinicalTrials.gov NCT06202677; https://clinicaltrials.gov/study/NCT06202677.

PMID:39680884 | DOI:10.2196/63316

J Chem Theory Comput. 2024 Dec 16. doi: 10.1021/acs.jctc.4c01389. Online ahead of print.

ABSTRACT

Free energy calculations for protein-ligand complexes have become widespread in recent years owing to several conceptual, methodological and technological advances. Central among these is the use of ensemble methods which permits accurate, precise and reproducible predictions and is necessary for uncertainty quantification. Absolute binding free energies (ABFEs) are challenging to predict using alchemical methods and their routine application in drug discovery has remained out of reach until now. Here, we apply ensemble alchemical ABFE methods to a large data set comprising 219 ligand-protein complexes and obtain statistically robust results with high accuracy (<1 kcal/mol). We compare equilibrium and nonequilibrium methods for ABFE predictions at large scale and provide a systematic critical assessment of each method. The equilibrium method is more accurate, precise, faster, computationally more cost-effective and requires a much simpler protocol, making it preferable for large scale and blind applications. We find that the calculated free energy distributions are non-normal and discuss the consequences. We recommend a definitive protocol to perform ABFE calculations optimally. Using this protocol, it is possible to perform thousands of ABFE calculations within a few hours on modern exascale machines.

PMID:39680850 | DOI:10.1021/acs.jctc.4c01389

Scand J Work Environ Health. 2024 Dec 16:4203. doi: 10.5271/sjweh.4203. Online ahead of print.

ABSTRACT

OBJECTIVES: The aim was to develop a gender-specific European job exposure matrix (EuroJEM) for occupational physical workload and study its predictive validity for musculoskeletal pain in four European cohorts.

METHODS: National, gender-specific JEM from Finland, France, Norway and Sweden, based on self-reported exposure information, were evaluated for similarities in exposures, exposure definitions, and occupational coding. The EuroJEM harmonized five exposures: heavy lifting, faster breathing due to heavy workload, kneeling/squatting, forward bent posture, and working with hands above shoulder level. Our expert panel addressed disagreements and missing information to reach consensus on exposure levels across occupations. To assess predictive validity of the EuroJEM, we examined associations between the harmonized exposure measures and self-reported musculoskeletal pain across the four cohorts.

RESULTS: The EuroJEM provides semi-quantitative exposure estimates for 374 ISCO-88 (COM) occupational codes. Five categories of exposure were defined by the proportion of workers exposed within each occupation. Comparable and statistically significant associations were found between EuroJEM exposures and low back, shoulder, and knee pain across all cohorts and genders, except for knee pain among women in the Finnish cohort. For instance, in both genders heavy lifting, faster breathing due to heavy workload, and forward bent posture were statistically significantly associated with low-back pain in all four cohorts, with OR ranging from 1.25-2.18 (men) and 1.23-2.04 (women).

CONCLUSIONS: Despite differences in study populations and outcome definitions, good predictive validity was observed in each national cohort, suggesting that EuroJEM can be an effective tool for exposure assessment in large-scale European epidemiological studies.

PMID:39680844 | DOI:10.5271/sjweh.4203

J Can Dent Assoc. 2024 Sep;90:o7.

ABSTRACT

OBJECTIVES: A growing body of literature highlights the negative impact of the COVID-19 pandemic on the mental health of health care professionals. This paper explores the effects of gender and work/life factors on dentists’ mental health before and during the pandemic.

METHODS: Data were obtained from a cross-sectional, online survey of Canadian dentists, which was part of a broader study of Canadian professionals’ mental health challenges conducted in 2020-2021. Using logistic regression, we compared the influence of life stress, work stress, gender and role in practice on dentists’ self-rated mental health before and during the pandemic.

RESULTS: Respondents reported that their mental health had worsened during the pandemic. Among survey respondents (n = 397), women dentists (50%) reported worse mental health than men (39%). Those who had higher levels of work and life stress reported more mental health challenges both before and during the pandemic.

CONCLUSIONS: Our findings point to the need for more attention to dentists’ mental health and highlight the need for gender-sensitive mental health resources and supports for Canadian dentists.

PMID:39680811

J Can Dent Assoc. 2024 Oct;90:o5.

ABSTRACT

OBJECTIVES: To compare trends in teaching and placement of composite resin versus amalgam in posterior restorations in Canadian dental schools with those in the United States.

METHODS: Secondary descriptive and statistical analyses were performed on data from 2 previous studies. The data consisted of responses to questionnaires on teaching policies and the proportion of posterior restorations (amalgam and composite resin) performed in Canadian and US dental schools. Fisher’s exact test and 2-sample z-test were used to compare the proportions.

RESULTS: Canadian dental schools allocated less time than US schools to teaching composite resin restorations (p = 0.006): 22.2% of Canadian schools versus 76.4% of US schools devoted more than 50% of preclinical teaching time to such restorations. Canadian dental schools also dedicated more time to teaching amalgam restorations (p = 0.041): 33.3% of Canadian schools versus 8.8% of US schools devoted 50-75% of preclinical teaching time to amalgam restorations. Between 2008 and 2018, a significantly higher proportion of composite resin restorations were performed in US dental schools than in Canadian schools (p < 0.001).

CONCLUSIONS: In Canadian dental schools, teaching of posterior composite resin restorations was more conservative than in US schools. There was no consensus among Canadian and US dental schools on composite resin preparation techniques or contraindications. Clear, standardized guidelines pertaining to composite resin teaching policies are suggested.

PMID:39680810

Am J Speech Lang Pathol. 2024 Dec 16:1-12. doi: 10.1044/2024_AJSLP-24-00238. Online ahead of print.

ABSTRACT

PURPOSE: The purpose of this study was to describe the evolution and prevalence of parent-reported problematic feeding behaviors and eating skills in infants born prior to 34 weeks at the time of eating solid foods between 8 and 24 months of age, and to explore the associations between problematic feeding and the impact on the parent and family.

METHOD: Parents of eligible children (N = 35) completed an online survey when their child was 8, 10, 12, 18, and 24 months corrected age. The survey included the Pediatric Eating Assessment Tool (PediEAT), Child Oral and Motor Proficiency Scale (ChOMPS), and the Feeding Impact Scales-Family and Parent.

RESULTS: The prevalence of problematic feeding behaviors, as measured by the PediEAT, decreased from 63% at 8 months to 29% at 24 months. The prevalence of problematic eating skills, as measured by the ChOMPS, ranged from 30% to 56% between 8 and 24 months, with the highest prevalence between 10 and 18 months. The impact of feeding on the family and parent, as measured by the Feeding Impact Scales, was higher in families of children with problematic feeding than those without problematic feeding; however, given the small sample size, this was only statistically significant at 10 and 24 months.

CONCLUSIONS: The prevalence of problematic feeding in this population of infants under 34 weeks was 43%-44% over the first 2 years of life. Infants born preterm should be considered at elevated risk for problematic feeding and monitored closely with timely referrals. Identifying prevention strategies in the neonatal intensive care unit will be critical.

PMID:39680806 | DOI:10.1044/2024_AJSLP-24-00238

Am J Speech Lang Pathol. 2024 Dec 16:1-14. doi: 10.1044/2024_AJSLP-23-00249. Online ahead of print.

ABSTRACT

INTRODUCTION: Naming difficulties are commonly reported in the acute and subacute stages of recovery of traumatic brain injury (TBI) and across severity levels. Previous studies, however, have used samples of mixed chronicity (acute and chronic) and severity (mild and severe) and then aggregated data across individuals from these distinct groups. Thus, we have little knowledge about the persistence of naming difficulties into the chronic stage of recovery in individuals with moderate-severe TBI.

PURPOSE: To increase the rigor and reproducibility of naming research in TBI, the present study sought to determine the presence and profile of naming disruptions into the chronic stage of moderate-severe TBI using a confrontation naming assessment.

METHOD: Thirty-three individuals aged 24-55 years in the chronic epoch of moderate-severe TBI and 33 demographically matched noninjured comparison (NC) participants completed the Philadelphia Naming Test (PNT). A mixed-effects logistic regression model predicting the probability of a correct response as a function of group was fit to the data.

RESULTS: Participants with TBI performed well on the PNT (all participants with TBI had over 90% accuracy). However, participants with TBI were statistically less likely to correctly name an item relative to demographically matched NC participants.

CONCLUSIONS: This study provides empirical evidence that naming difficulties persist into the chronic epoch of moderate-severe TBI. Despite high accuracy on the PNT, nearly 60% of these individuals with TBI reported continued difficulty with word finding in their daily lives. This discrepancy leaves open the possibility that, at this stage of injury, word-finding issues may be more reliably evoked and studied when the assessment is embedded within cognitively demanding and ecologically valid contexts (i.e., discourse, conversation). Further investigation of naming deficits in chronic moderate-severe TBI using a more naturalistic assessment is warranted.

PMID:39680803 | DOI:10.1044/2024_AJSLP-23-00249

Int J Radiat Biol. 2024 Dec 16:1-11. doi: 10.1080/09553002.2024.2440870. Online ahead of print.

ABSTRACT

PURPOSE: In cases of radiological or nuclear events, biological dosimetry enables decisions whether an individual was exposed to ionizing radiation and the estimation of the dose. Several statistical methods are used to assess uncertainties. The stringency of the applied method has an impact on the lowest dose that can be detected. To obtain reliable and comparable results, it is crucial to harmonize the applied statistical methods.

MATERIALS AND METHODS: The decision threshold and detection limit of the statistical methods were derived for variable cell numbers. The coverage of the 95% confidence intervals as well as the false-positive and false-negative rates of the methods were compared based on simulations. The evaluated methods included a graphical method, the propagation of errors and a Bayesian method.

RESULTS: The minimum resolvable doses, the doses at the detection limit and the coverage were relatively variable between the compared methods. The Bayesian method showed the best coverage, lowest resolvable doses and had false-positive rates close to 5%. The graphical method with the combination of two 83% confidence intervals also showed promising results. The other methods were either too conservative or underestimated the uncertainties for some doses or cell numbers.

CONCLUSIONS: The assessment of the lower dose limits is a central part of biological dosimetry and the applied statistical methods have a strong influence on the interpretation of the results. Simulations enable comparisons between methods and provide important information for the harmonization and standardization of the uncertainty assessment.

PMID:39680794 | DOI:10.1080/09553002.2024.2440870

J Speech Lang Hear Res. 2024 Dec 16:1-12. doi: 10.1044/2024_JSLHR-24-00360. Online ahead of print.

ABSTRACT

PURPOSE: When using the spatiotemporal index (STI) to measure variability across repetitions of the same stimulus, researchers will typically screen and remove productions that contain errors or disfluencies. However, this screening process is highly subjective, reduces the amount of data available, and may generate samples that are less representative of true speech difficulties. In this study, we quantify the degree to which the STI is skewed by the inclusion of highly deviating productions and whether alternative calculations could better facilitate their inclusion.

METHOD: First, we conducted a controlled simulation to quantify how highly deviating productions skew STI values. The traditional STI calculation was compared to three robust alternative measures proposed to reduce the influence of outlying productions. Next, using audio recordings from typically developing (TD) children and children with childhood apraxia of speech (CAS), we investigated how effectively each STI measure differentiated the two groups.

RESULTS: Simulation findings demonstrated that the STI can be heavily skewed (more than doubling in value) by the inclusion of a single outlying production. In contrast, the robust alternative measures were all able to incorporate multiple outlying productions before their value was significantly altered. The proposed best-5 STI measure produced larger group differences between TD children and children with CAS compared to the traditional STI in both “Mom pets the puppy” and “Buy Bobby a puppy” stimuli.

CONCLUSIONS: The STI is highly sensitive to outlying productions and requires careful consideration of the repetitions included in its calculation. However, conservative approaches to data removal may be problematic when studying populations that are prone to fluency errors. In these scenarios, more robust alternatives to the STI, such as the best-5 STI measure, may provide a more practical approach to measuring speech variability.

SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.27973236.

PMID:39680792 | DOI:10.1044/2024_JSLHR-24-00360

Int J Epidemiol. 2024 Dec 16;54(1):dyae164. doi: 10.1093/ije/dyae164.

ABSTRACT

BACKGROUND: There have been reports of sharp declines in acute coronary syndrome (ACS) during the COVID-19 pandemic. The study aims to assess nationwide ACS emergency department (ED) visit rates across age and sex subgroups and the general population, with a comparison before and throughout the pandemic’s various phases.

METHODS: A multiple interrupted time series analysis was used to assess 61 349 ACS nationwide hospital visits from January 2018 to December 2021 at monthly intervals. The study period was divided into three periods: January 2018-February 2020 (pre-pandemic period); March 2020-January 2021 (early-pandemic period); February 2021-December 2021 (late-pandemic period). Segmented regression with a seasonally adjusted autoregressive moving average structure was used to build predictive models with an estimated reference trendline (counterfactual).

RESULTS: Over 11 months of the early-pandemic period (lockdowns), the largest decrease in visits was seen in women aged 65 and above, of 18.4% [incidence rate ratio (IRR) 0.82; 95% confidence interval (CI) 0.77-0.86]. The lowest decrease was observed in men aged 25-64, of 7.2% (IRR 0.93; 0.91-0.94). During the late-pandemic period, which included high vaccination coverage and no lockdowns, the largest further decrease was in women aged 25-64 of 20.1% (IRR 0.80; 0.75-0.84) on average.

CONCLUSIONS: The pandemic influenced ACS ED visits variably, with substantial declines during phases of high COVID-19 morbidity and mortality. Older individuals, particularly women, demonstrated the largest decrease in ACS ED visits, highlighting the need for tailored public health strategies to maintain public confidence in access to critical care during future health emergencies.

PMID:39680786 | DOI:10.1093/ije/dyae164