NMR Biomed. 2022 Jul 11:e4800. doi: 10.1002/nbm.4800. Online ahead of print.
ABSTRACT
BACKGROUND: Quantitative MRI can detect the early biochemical changes in the cartilage; however, the conventional techniques only measure one parameter (e.g., T1 , T2 , and T1ρ ) at a time while being comparatively slow.
PURPOSE: We implement a 3D-magnetic resonance fingerprinting (3D-MRF) technique for simultaneous, volumetric mapping of T1 , T2, and T1ρ in the knee articular cartilage under 9 minutes.
STUDY TYPE: Prospective.
FIELD STRENGTH/SEQUENCE: 3D-MRF pulse sequence for 3T.
SUBJECTS AND PHANTOM: 11 healthy volunteers (mean age: 53 ± 9) and 5 mild knee OA patients (KL:2, mean age: 60 ± 4) and NIST/ISMRM system phantom ASSESSMENT: Proton density (PD) image, and T1 , T2, T1ρ relaxation times, and B1+ were estimated in NIST/ISMRM system phantom as well as the human knee medial (MFC) and lateral (LFC) femur, medial (MTC) and lateral (LTC) tibia, and patellar cartilages (PC).
STATISTICAL TESTS: The repeatability and reproducibility of the proposed technique were assessed in the phantom using the analysis of the Bland-Altman plots. The intra-subject repeatability was assessed with the coefficient of variation (CV), and the root mean square CV (rmsCV). Mann-Whitney U test was used to assess the difference between healthy subjects and mild knee OA patients.
RESULTS: The Bland-Altman plots in the NIST/ISMRM phantom demonstrated an average difference of 0.001 ± 015%, 1.2 ± 7.1%, and 0.47 ± 3% between two scans from the same 3T scanner (repeatability), and 0.002 ± 015%, 0.62 ± 10.5%, and 0.97 ± 14% between the scans acquired on two different 3T scanners (reproducibility) for T1 , T2 , and T1ρ , respectively. The in-vivo knee study showed excellent repeatability with rmsCV less than 1%, 2%, and 1% for T1 , T2 , and T1ρ , respectively. T1ρ relaxation time in the mild knee OA patients was significantly higher (p < 0.05) than in healthy subjects.
DATA CONCLUSION: The proposed 3D-MRF sequence is fast, reproducible, robust to B1+ inhomogeneity, and can simultaneously measure the T1 , T2 , T1ρ , and B1+ volumetric maps of the knee joint in a single scan within clinically feasible scan time.
PMID:35815660 | DOI:10.1002/nbm.4800