JPEN J Parenter Enteral Nutr. 2022 Nov 17. doi: 10.1002/jpen.2465. Online ahead of print.
ABSTRACT
BACKGROUND: Short bowel syndrome is the most common cause of intestinal failure (IF) in infants. We aimed to evaluate growth, nutritional intakes and predictors of weaning from parenteral nutrition (PN) of infants with IF.
METHODS: Clinical parameters, nutritional intakes and body weight and length z-scores were compared monthly from1st to 12th and at 18 and 24 months of life among infants on PN and those weaned. Logistic regression analysis was conducted to explore the predictors of weaning.
RESULTS: We included 23 infants (10/23 weaned). Median [range] birth weight and gestational age were: 1620 [590;3490] g and 31 [24;39] weeks respectively. All infants showed a growth retardation with similar median delta weight z-score from birth to discharge: -1.48 [-1.92;-0.94] in not-weaned and -1.18 [-2.70;0.31] in weaned infants, p=0.833 and a subsequent regain after the discharge: 0.20 [-3.47;3.25] and 0.84 [-0.03;2.58] respectively, p=0.518. No differences in length z-score were found among groups. After the sixth month, infants weaned from PN received lower PN energy and protein intakes compared to not-weaned. Infants weaned from PN showed lower parenteral nutrition dependency index (PNDI%) from 5 months onwards (45% for weaned and 113% for not-weaned infants at 5 months: p<0.001). The Belza’s score, a predictor of enteral autonomy computed at 6 months, is associated with being weaned from PN within 24 months (OR:1.906; p=0.039).
CONCLUSIONS: Infants weaned and not-weaned showed similar growth patterns. Our findings support the clinical relevance of Belza’s score and PNDI% as predictors of weaning from PN. Keywords This article is protected by copyright. All rights reserved.
PMID:36398420 | DOI:10.1002/jpen.2465
