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HLA-G*14 bp indel variant in autism spectrum disorder in a population from southern Brazil

J Neuroimmunol. 2023 Aug 30;383:578194. doi: 10.1016/j.jneuroim.2023.578194. Online ahead of print.


Altered immune response during pregnancy has been associated with ASD susceptibility. HLA-G is expressed by the trophoblast at the maternal/fetal interface and induces allogenic tolerance toward the fetus. A 14-bp insertion in the HLA-G 3’UTR (rs371194629) was associated with reduced levels of HLA-G. We aimed to assess the influence of the HLA-G*14 bp indel variant in ASD susceptibility and symptomatology in a Brazilian admixed sample. The insertion genotype (14 bp+/14 bp+) was firstly associated with hetero aggression, but statistical significance was lost after correction (p = 0.035, pcorrected = 0.35). No association between the HLA-G variant and susceptibility to ASD or differential clinical manifestations were observed.

PMID:37683302 | DOI:10.1016/j.jneuroim.2023.578194

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