Category: Nevin Manimala

Support Care Cancer. 2023 Apr 12;31(5):256. doi: 10.1007/s00520-023-07717-3.

ABSTRACT

Early-stage Hodgkin lymphoma has become one of the most curable hematologic malignancies. Depending upon the disease location, possible toxicities, and patient preference, chemotherapy alone with ABVD remains an accepted treatment modality for this disease. There remains a paucity of data regarding the longitudinal trajectory of health-related quality of life (HRQoL) in patients treated for HL. The impact of disease and treatment on HRQoL is increasingly important to understand as the number of long-term survivors increases. We report the longitudinal HRQoL using data prospectively collected from diagnosis up to 10 years post-treatment in the ABVD arm of the HD.6 randomized controlled trial for early-stage HL patients (N=169). We analyzed HRQoL using the EORTC QLQ-C30 collected at baseline, 3 months, 6 months, and 12 months after completion of chemotherapy and yearly up to year 10. Clinically and statistically significant improvements were noted for specific domains including emotional (3 months post-treatment), social (12 months post-treatment) and financial functioning (2 years post-treatment), and the specific symptom of fatigue (6 months post-treatment) during the follow-up period. To our knowledge, this is the first prospective, longitudinal analysis of HRQoL specifically among patients with early-stage HL treated with ABVD therapy alone. Although improvements were noted, sustained clinically and statistically significant improvements were noted only in select symptoms emphasizing the need to better understand and optimize HRQoL among this patient group.

PMID:37043087 | DOI:10.1007/s00520-023-07717-3

J Anesth. 2023 Apr 12. doi: 10.1007/s00540-023-03192-6. Online ahead of print.

ABSTRACT

PURPOSE: To assess the efficacy of pericapsular nerve group (PENG) block combined with lateral femoral cutaneous nerve (LFCN) block in controlling postoperative pain and promoting recovery of lower extremity after total hip arthroplasty (THA), and to compare its effectiveness with supra-inguinal fascia iliaca compartment block (S-FICB).

MATERIALS AND METHODS: 92 patients undergoing THA with general anesthesia were randomly allocated to receive either a PENG with LFCN block (n = 46) using 30 ml 0.33% ropivacaine (20 ml for PENG block, 10 ml for LFCN block), or an S-FICB (n = 46) using 30 ml 0.33% ropivacaine. The primary outcome was the time to first postoperative walk. The secondary outcomes included intraoperative remifentanil consumption, postoperative hip flexion degree and muscle strength of the operative lower limbs in the supine position, pain scores (static and dynamic), rescue analgesia, postoperative nausea and vomiting (PONV), and nerve block-related complications.

RESULTS: The combination of PENG with LFCN blocks resulted in an earlier first postoperative walking time (19.6 ± 9.6 h vs 26.5 ± 8.2 h, P < 0.01), greater postoperative hip flexion degree at 6 h, 24 h and 48 h (all P < 0.01), and higher muscle strength of the operative lower limbs at 6 h after surgery (P = 0.03) compared to S-FICB. The difference in pain scores (static and dynamic) was only statistically significant at 48 h (P < 0.05). There were no differences in the other outcomes.

CONCLUSIONS: PENG with LFCN blocks is more effective than S-FICB in shortening the time to first postoperative walk and preservation hip motion after THA, which makes it a suitable addition to enhanced recovery programs following surgery.

PMID:37043081 | DOI:10.1007/s00540-023-03192-6

Matern Child Health J. 2023 Apr 12. doi: 10.1007/s10995-022-03524-0. Online ahead of print.

ABSTRACT

BACKGROUND: Recent legislative decisions in the United States have encouraged discussion about national parental leave programs. Currently, over 47% of the United States workforce is female. However, the United States is the only nation of the 37 member countries in the Organization for Economic Co-Operation and Development (OECD) to have no national requirement for maternity leave. The first few months of a child’s life are vital to their physical and mental development. Likewise, a gradual return to pre-partum functioning is important for a newly postpartum woman. While it has been shown that maternity leave positively impacts various measures of maternal and infant mental and physical health, we lack consensus on the optimal length of paid or unpaid maternity leave. Accordingly, we conducted a systematic review and meta-analysis to evaluate the optimal length of paid or unpaid maternity leave to encourage maternal and infant mental and physical health in the United States.

METHODS: A systematic review and meta-analysis were conducted to synthesize and critically evaluate the current research investigating the association between maternity leave and maternal and infant mental and physical health using the Preferred Reporting in Systematic Reviews and Meta-Analyses guidelines. Databases EMBASE, PsycInfo, and PubMed were searched using specific inclusion and exclusion criteria. Methodological Index for Non-Randomized Studies scale assessed the methodological quality of the included eligible studies. The magnitude of heterogeneity between-study was tested using The Cochrane χ² test and the Moran’s I² statistic. Possible publication bias was assessed through the funnel plot and the Egger regression test. A p-value of < 0.10 will be considered as an indication for the existence of potential publication bias. All statistical analyses were carried out with Stata software version 15.

RESULTS: A total of 21 studies were analyzed. It was found that longer maternity leave may decrease rates of maternal mental and physical health complaints. It was also found that longer maternity leave leads to more positive mother-child interactions, decreased infant mortality, and longer periods of breastfeeding.

CONCLUSION: Maternity leave of 12 weeks or more confers the greatest benefit for mothers and their infants.

PMID:37043071 | DOI:10.1007/s10995-022-03524-0

Bull Exp Biol Med. 2023 Apr 12. doi: 10.1007/s10517-023-05766-6. Online ahead of print.

ABSTRACT

The frequency of D. melanogaster embryonic death was estimated using the method of dominant lethal mutations after exposure to ionizing γ-radiation and non-ionizing pulsed magnetic field. γ-Radiation had a dose-dependent mutational effect on D. melanogaster. A pronounced increase in embryonic death was observed starting from a dose of 3 Gy and reaches a plateau at 60 Gy due to the maximum death of eggs. When D. melanogaster was exposed to pulsed magnetic field, the effect did not depend on the exposure time; a statistically significant genotoxic effect was detected after 5-h exposure.

PMID:37043061 | DOI:10.1007/s10517-023-05766-6

Clin Oral Investig. 2023 Apr 12. doi: 10.1007/s00784-023-04992-6. Online ahead of print.

ABSTRACT

OBJECTIVES: This study aimed to train deep learning models for recognition of contiguity between the mandibular third molar (M3M) and inferior alveolar canal using panoramic radiographs and to investigate the best effective fold of data augmentation.

MATERIALS AND METHODS: The total of 1800 M3M cropped images were classified evenly into contact and no-contact. The contact group was confirmed with CBCT images. The models were trained from three pretrained models: AlexNet, VGG-16, and GoogLeNet. Each pretrained model was trained with the original cropped panoramic radiographs. Then the training images were increased fivefold, tenfold, 15-fold, and 20-fold using data augmentation to train additional models. The area under the receiver operating characteristic curve (AUC) of the 15 models were evaluated.

RESULTS: All models recognized contiguity with AUC from 0.951 to 0.996. Ten-fold augmentation showed the highest AUC in all pretrained models; however, no significant difference with other folds were found. VGG-16 showed the best performance among pretrained models trained at the same fold of augmentation. Data augmentation provided statistically significant improvement in performance of AlexNet and GoogLeNet models, while VGG-16 remained unchanged.

CONCLUSIONS: Based on our images, all models performed efficiently with high AUC, particularly VGG-16. Ten-fold augmentation showed the highest AUC by all pretrained models. VGG-16 showed promising potential when training with only original images.

CLINICAL RELEVANCE: Ten-fold augmentation may help improve deep learning models’ performances. The variety of original data and the accuracy of labels are essential to train a high-performance model.

PMID:37043029 | DOI:10.1007/s00784-023-04992-6

Eur Arch Otorhinolaryngol. 2023 Apr 12. doi: 10.1007/s00405-023-07961-7. Online ahead of print.

ABSTRACT

PURPOSE: The main objective of this study is to evaluate the short-term and long-term audiological outcomes in patients who underwent cochlear implantation with a robot-assisted system to enable access to the cochlea, and to compare outcomes with a matched control group of patients who underwent cochlear implantation with conventional access to the cochlea.

METHODS: In total, 23 patients were implanted by robot-assisted cochlear implant surgery (RACIS). To evaluate the effectiveness of robotic surgery in terms of audiological outcomes, a statistically balanced control group of conventionally implanted patients was created. Minimal outcome measures (MOM), consisting of pure-tone audiometry, speech understanding in quiet and speech understanding in noise were performed pre-operatively and at 3 months, 6 months, 12 months and 2 years post-activation of the audioprocessor.

RESULTS: There was no statistically significant difference in pure-tone audiometry, speech perception in quiet and speech perception in noise between robotically implanted and conventionally implanted patients pre-operatively, 3 months, 6 months, 12 months and 2 years post-activation. A significant improvement in pure-tone hearing thresholds, speech understanding in quiet and speech understanding in noise with the cochlear implant has been quantified as of the first measurements at 3 months and this significant improvement remained stable over a time period of 2 years for HEARO implanted patients.

CONCLUSION: Clinical outcomes in robot-assisted cochlear implant surgery are comparable to conventional cochlear implantation. CLINICALTRAILS.

GOV TRAIL REGISTRATION NUMBERS: NCT03746613 (date of registration: 19/11/2018), NCT04102215 (date of registration: 25/09/2019).

PMID:37043021 | DOI:10.1007/s00405-023-07961-7

Environ Monit Assess. 2023 Apr 12;195(5):555. doi: 10.1007/s10661-023-11137-5.

ABSTRACT

The general circulation models (GCMs) and emission scenarios (RCP 4.5 and 8.5) have proven to be significantly functional in evaluating the impacts of climate change (CC) on hydrology, although their performance and accuracy varies on a regional scale. The objective of the present study is to evaluate the performance of five CMIP5 GCMs (CanESM2, BNU-ESM, CNRM-CM5, MPI-ESM-LR and MPI-ESM-MR) on a regional scale in the West Flowing River Basins-2 (WFRB-2) in India to model the impact of CC and its scenario uncertainty using reliability ensemble average (REA) method. For quantifying the results, the upper, middle and lower regions of WFRB-2 are separately analysed. The MPIMR and MPILR GCM model shows highest reliability factor range (0.3-0.6) in predicting the annual mean and annual maximum rainfall for most of the grids in the region. The GCM-simulated runoff using VIC (variable infiltration capacity) model is evaluated using statistical parameters such as root mean square error (RMSE), percentage bias (Pbias) and standard deviation (Std). The annual mean (maximum) runoff obtained using REA ensemble shows least RMSE, Pbias and Std values, i.e. 21.08%, 9.10 mm and 8.9 mm (6%, 39.1 mm, 39.1 mm), respectively for the middle region, which demonstrates higher reliability of GCM outputs in the flood-prone regions of WFRB-2. Furthermore, the future projection of annual maximum rainfall/runoff shows an increase of 50 mm/15 mm in the near future (2011-2040) for lower and 20 mm/6 mm for middle regions, which may cause flooding activities in the lower and middle region of WFRB-2.

PMID:37043020 | DOI:10.1007/s10661-023-11137-5

Skeletal Radiol. 2023 Apr 12. doi: 10.1007/s00256-023-04327-2. Online ahead of print.

ABSTRACT

OBJECTIVES: Determine whether MR imaging findings or demographics predict surgical management in patients with first MTP joint injuries.

MATERIALS AND METHODS: Retrospective study of 161 forefoot MRs for traumatic first MTP injury (M:F 92:69, mean age 33 ± 13 yrs.). Two radiologists reviewed imaging for ligamentous, osseous, and tendinous injuries. Ligaments and tendons were graded as 0:normal, 1:sprain or strain, 2:partial tear, 3:complete tear. Osseous injuries were classified as edema, fracture, or cartilage injury. Clinical data obtained included sex, age, injury acuity, sport participation, level of sport, and treatment. Imaging findings and demographic data were assessed to determine predictive factors for surgical management. Statistics included kappa, chi-squared, Fisher’s exact, and logistic regression.

RESULTS: Logistic regression (odds ratio [95% CI], p-value) showed that grade 2 or 3 injuries of the plantar ligamentous complex (2.87, [1.10, 7.48], p = 0.031), grade 2 or 3 injuries of the medial collateral ligament (3.24, [1.16, 9.08], p = 0.025), and participation in collegiate or professional sports (4.34 [1.64, 11.52], p = 0.003) were associated with an increased rate of surgical intervention. k = ligamentous injury (0.71-0.83), osseous trauma (0.88-0.95), and tendon injury (0.78). All other imaging findings and demographic factors were not significant predictors of surgery (p > 0.05).

CONCLUSION: Participation in collegiate or professional sports and tears of the plantar ligamentous complex or medial collateral ligament predicted surgical management in patients with first MTP trauma.

PMID:37043019 | DOI:10.1007/s00256-023-04327-2

Ophthalmologie. 2023 Apr 12. doi: 10.1007/s00347-023-01839-z. Online ahead of print.

ABSTRACT

OBJECTIVE: The aim of this study was to analyze the effect of corneal cross-linking (CXL) on corneal biomechanics and visual acuity.

PATIENTS AND METHODS: The examination results before and after CXL in 56 eyes of 56 patients between 2017 and 2021 were evaluated retrospectively. The last preoperative examination was compared to the postoperative follow-up values after 6 and 12 months. The main outcome measures included various biomechanical parameters from the Corvis ST (CST), Pentacam and the visual acuity (logMAR, “logarithm of the Minimal Angle of Resolution”). For longitudinal evaluation, a general linear model for repeated measurements was used. A p-value of less than 0.05 was considered to show a statistically significant result. Bonferroni correction was applied for multiple comparisons.

RESULTS: The maximum corneal refractive power K_max decreased slightly without statistical significance from 57.1 ± 6.1 diopters (dpt) to 56.6 ± 6.3 dpt after 6 months (p = 0.076) and 56.8 ± 6.6 dpt after 12 months (p = 0.443). The Pentacam parameter Belin/Ambrósio Enhanced Ectasia Total Deviation Display (BAD D) showed a statistically significant increase from the preoperative value of 8.4 ± 3.7 to the postoperative value of 9.1 ± 3.6 after 6 months (p < 0.001) and to 8.9 ± 3.5 after 12 months (p = 0.051). The CST parameter Ambrósio’s relational thickness to horizontal profile (ARTh) decreased statistically significantly from 229.9 ± 109.6 to 204.8 ± 84.9 at 6 months (p = 0.017) and 205.3 ± 93.7 at 12 months (p = 0.022). The CST parameter stiffness parameter A1 (SP A1) increased slightly from the preoperative value 69.9 ± 17.2 to 70.4 ± 17.2 after 6 months (p = 1) and 71 ± 18.2 after 1 year (p = 1). Mean best-corrected visual acuity (logMAR) showed an improvement from 0.39 ± 0.3 to 0.34 ± 0.3 at 6 months (p = 0.286) and to 0.31 ± 0.3 at 12 months (p = 0.077). Regarding the ABCD classification, the parameters were determined preoperatively with an average of A2B3C1D2. They showed the same value of A2B3C1D2 after 6 and 12 months.

CONCLUSION: In progressive keratoconus, corneal cross-linking has the potential to positively influence the biomechanics of the cornea and visual acuity as a low complication treatment option.

PMID:37043004 | DOI:10.1007/s00347-023-01839-z

Exp Brain Res. 2023 Apr 12. doi: 10.1007/s00221-023-06614-9. Online ahead of print.

ABSTRACT

This experiment investigated the role of anticipatory and reflexive compensatory neuromotor control in catching errors occurring under load uncertainty. Participants performed 64 trials of a one-handed ball catching task using visually identical balls of four different weights without knowing the weight of the ball on each trial. Anticipatory and reflexive compensatory muscle activation were recorded in five muscles (anterior deltoid, biceps brachii, wrist flexors group, triceps brachii, lumbar erector spinae) using the EMG integral. In each muscle, the anticipatory and reflexive compensatory muscle activation were compared between successful catches and catching errors for the lightest ball and the heaviest ball. Anticipatory muscle activation was not implicated in errors made with the lightest ball. However, reflexive compensatory muscle activation in the anterior deltoid, biceps brachii, and wrist flexors were implicated in errors made with the lightest ball. Specifically, catching errors with the lightest ball were characterized by elevated reflexive compensatory muscle activation. In the case of the heaviest ball, both anticipatory (anterior deltoid, wrist flexors) and reflexive compensatory muscle activation (anterior deltoid, biceps brachii, wrist flexors) were implicated in catching errors. That is, catching errors with the heaviest ball were characterized by lower anticipatory and reflexive compensatory muscle activation. Results are considered in the context of the likely influence of limb compliance in catching under load uncertainty.

PMID:37042997 | DOI:10.1007/s00221-023-06614-9