Category: Nevin Manimala

World J Urol. 2023 Jan 31. doi: 10.1007/s00345-023-04301-6. Online ahead of print.

ABSTRACT

PURPOSE: To investigate the influencing factors of acute kidney injury (AKI) following retrograde intrarenal surgery (RIRS).

METHODS: The data of patients who underwent RIRS for kidney stones between January 2018 and June 2022 at two tertiary centers were retrospectively analyzed. Demographic data of patients were obtained. According to kidney disease: Improving Global Outcomes (KDIGO) criteria, those with and without AKI were divided into two groups. Preoperative, intraoperative, and postoperative predictive factors of patients were investigated between the groups. In addition, the influencing factors of AKI were examined by multivariate analysis.

RESULTS: This study included 295 (35.7%) women and 532 (64.3%) men. The mean age was 50.03 ± 15.4 years (range 18-89), and mean stone size was 15.5 ± 6.1 mm (range 6-47). Overall, 672 of patients (81.3%) were stone-free after the initial treatment. According to KDIGO, 110 of patients (13.3%) had AKI during the postoperative period. Univariate analysis showed that stone size (P = .003), previous stone surgery (P = .010), renal malformations (P = .017), high operative time (P = < .001), high preoperative creatinine value (P = .036), intraoperative complications (P = .018), and postoperative urinary tract infection (P = .003) had significant influence on the AKI after RIRS. Multivariate analysis excluded previous stone surgery, high preoperative creatinine value, renal malformations, and intraoperative complications from the logistic regression model, whereas other factors maintained their statistically significant effect on AKI, indicating that they were independent predictors.

CONCLUSIONS: Stone size, operative time, postoperative urinary tract infection, and diabetes mellitus are significant predictors of AKI. During RIRS, urologists should consider the factors that increase the risk of AKI and evaluate the treatment outcomes based on these factors.

PMID:36719465 | DOI:10.1007/s00345-023-04301-6

Microb Ecol. 2023 Jan 31. doi: 10.1007/s00248-023-02183-0. Online ahead of print.

ABSTRACT

How the coral microbiome responds to oceanic pH changes due to anthropogenic climate change, including ocean acidification and deliberate artificial alkalization, remains an open question. Here, we applied a 16S profile and GeoChip approach to microbial taxonomic and gene functional landscapes in the coral Galaxea fascicularis under three pH levels (7.85, 8.15, and 8.45) and tested the influence of pH changes on the cell growth of several coral-associated strains and bacterial populations. Statistical analysis of GeoChip-based data suggested that both ocean acidification and alkalization destabilized functional cores related to aromatic degradation, carbon degradation, carbon fixation, stress response, and antibiotic biosynthesis in the microbiome, which are related to holobiont carbon cycling and health. The taxonomic analysis revealed that bacterial species richness was not significantly different among the three pH treatments, but the community compositions were significantly distinct. Acute seawater alkalization leads to an increase in pathogens as well as a stronger taxonomic shift than acidification, which is worth considering when using artificial ocean alkalization to protect coral ecosystems from ocean acidification. In addition, our co-occurrence network analysis reflected microbial community and functional shifts in response to pH change cues, which will further help to understand the functional ecological role of the microbiome in coral resilience.

PMID:36719456 | DOI:10.1007/s00248-023-02183-0

Int Urogynecol J. 2023 Jan 31. doi: 10.1007/s00192-023-05467-8. Online ahead of print.

ABSTRACT

INTRODUCTION AND HYPOTHESIS: Both urogynecologic surgeries and transdermal scopolamine (TDS) patches are independently associated with postoperative urinary retention (POUR). It is unclear if the risk of POUR increases when these interventions are used in combination. This systematic review and meta-analysis aim to synthesize current evidence to optimize clinical management and outcomes for patients undergoing urogynecologic procedures.

METHODS: This systematic review was conducted in concordance with the PRISMA 2020 guidelines. MEDLINE, ClinicalTrials.gov, and Cochrane Library were searched. Publications were filtered by inclusion and exclusion criteria. Inclusion criteria required: (1) preoperative or perioperative application of TDS, (2) surgery indicated for stress urinary incontinence and/or pelvic organ prolapse, (3) results given for postoperative voiding trials, and (4) were available in English. Exclusion criteria included: (1) oral or parenteral formulations of scopolamine, (2) administration of alternative preoperative antiemetics, and (3) use of combination antiemetic therapy. Quality was assessed using the Joanna Briggs Institute Checklist. Publication bias was evaluated via the ROBINS-I assessment tool, and Egger regression and Begg and Mazumumdar rank correlation tests. A meta-analysis was conducted using Meta-Essentials Excel Workbook.

RESULTS: Four publications were identified which complied with inclusion and exclusion criteria. Included studies comprised 752 patients (237 experimental group, 515 control group). All were retrospective cohort studies conducted via chart review in America. Meta-analysis revealed a risk ratio (RR) of 2.35 with a confidence interval (CI) of 0.61 to 9.07, indicating a positive association between TDS and POUR, but without statistical significance.

CONCLUSIONS: Current evidence suggests that TDS application may be associated with increased risk of POUR following urogynecologic procedures. While research on this topic is greatly limited, this systematic review and meta-analysis highlights that alternative antiemetic therapy may be necessary for patients undergoing such interventions in effort to limit the risk of POUR.

PMID:36719449 | DOI:10.1007/s00192-023-05467-8

J Cosmet Dermatol. 2023 Jan 31. doi: 10.1111/jocd.15648. Online ahead of print.

ABSTRACT

INTRODUCTION: Melasma is a human melanogenesis dysfunction that results in localized, chronic acquired hypermelanosis of the skin difficult to treat.

METHODS: This prospective, randomized, single-blind, study aimed to compare the efficacy and tolerability of a liposomal emulsion based on Politranexamide® (SAMPLE A) with that of a competitor based on acetylglucosamine, ethyl linoleate and phenyl ethyl resorcinol (SAMPLE B) in patients affected by facial melasma on 26 patients. Disease severity was assessed by the Melasma Area Severity Index (MASI) at baseline and after 6 and 12 weeks of therapy. All patients were subjected to photo documentation using DermaView camera and Antera 3D camera.

RESULTS: The mean MASI score at baseline was 10.93 ± 7 in the group A and 9.34 ± 6.29 in the group B, respectively. A significant decrease in MASI score from baseline was noted in both treatment groups as early as 6 weeks of follow-up (p = 0.00096 for SAMPLE A and p = 0.0049 for SAMPLE B) and was confirmed at the end of the treatment (p = 0.0006 for SAMPLE A and p = 0.00039 for SAMPLE B). Intergroup comparison revealed a greater improvement of melasma among patients in group A compared to those in group B that was quite statistically significant at weeks 6 (p = 0.055009) and significant after 12 weeks of follow-up (p = 0.032942). Both treatment groups experienced an improvement in Antera average level of melanin.

CONCLUSION: Our results suggested Politranexamide® to be a useful and safe therapeutic option in treating melasma, more effective than competitor used in this study.

PMID:36718844 | DOI:10.1111/jocd.15648

J Cosmet Dermatol. 2023 Jan 31. doi: 10.1111/jocd.15643. Online ahead of print.

ABSTRACT

BACKGROUND: The perpendicular plate of ethmoid (PPE) was used to correct short noses in rhinoplasty in Asians, but the safe harvest of the plate and the assessment of its clinical application has been perplexing to plastic surgeons.

AIMS: To explore how to safely cut the perpendicular plate of ethmoid bone and evaluate its application effect.

PATIENTS/METHODS: A finite element model was established to guide the clinical operation. A total of 30 patients with short noses were selected. Among them, 15 patients used autologous septal cartilage to lengthen the nasal tip, and 15 patients used the PPE to strengthen the L-shape nasal septum. The differences in the esthetic parameters of the nose, complications, and patients’ satisfaction were compared between the two groups.

RESULTS: Significant differences were noted in the nasal dorsal length (p = 0.001), Goode’s ratio (p = 0.001), and nasofrontal angle (p = 0.003) after rhinoplasty, and no significant differences were noted in any of the esthetic parameters between the two groups. The symptoms of nasal obstruction in the experimental group were significantly lighter than those in the control group (p = 0.04). There was no statistically significant difference in the doctors’ assessment of outcomes between the two groups (p = 0.48).

CONCLUSION: The safest region to harvest the PPE is in the middle and lower third. Rhinoplasty improves the esthetics of the patient’s nose. The PPE used to strengthen the L-shape nasal septum structure has a smaller probability of nasal septal deviation with the time in Asian short noses.

PMID:36718843 | DOI:10.1111/jocd.15643

J Cosmet Dermatol. 2023 Jan 31. doi: 10.1111/jocd.15609. Online ahead of print.

ABSTRACT

BACKGROUND: Acne has a high impact on patients being a chronic, common, and visible skin condition. Knowledge regarding treatment improves outcomes. The Cardiff Acne Disability Index (CADI) is commonly used in clinical practice for quality-of-life assessment. It has been validated in many languages, however, not in Romanian.

AIMS: To validate the Romanian adaptation of the CADI and educational materials for acne patients.

PATIENTS AND METHOD: A 12-week prospective cross-sectional Web-based study, including 3rd- to 5th-year medical students attending our university was conducted. We obtained permission from the CADI copyright owner and performed the steps of the standardized translation process. The Romanian CADI adaptation was delivered online in a test-retest setup, during which participants were offered acne educational materials and completed a knowledge evaluation questionnaire.

RESULTS: A total of 95 complete answers were analyzed. The Romanian CADI adaptation showed good internal consistency, with Cronbach’s α = 0.807 in the first application and Cronbach’s α = 0.839 in the second. High test-retest reliability was observed, with interclass correlation coefficient ICC = 0.987 and Spearman’s rank correlation coefficient r_s = 0.970 for the overall CADI scores between the two administrations. The mean baseline score in the knowledge evaluation questionnaire was 15.52 points (±1.556), with a statistically significant improvement after exposure to the educational material (Z = -7.207, p < 0.001). This material was considered useful or very useful by 78(82.8%) participants.

CONCLUSION: Romanian acne patients can benefit from CADI, a reliable and disease-specific tool for quality-of-life evaluation, together with validated, guideline-aligned educational material in their language.

PMID:36718840 | DOI:10.1111/jocd.15609

J Cosmet Dermatol. 2023 Jan 31. doi: 10.1111/jocd.15622. Online ahead of print.

ABSTRACT

BACKGROUND: Oral licen planus (OLP) is a chronic inflammatory disease and may have immunological background. Both intralesional injection of PRP and steroids succeeded in treating and decreasing recurrence of the disease.

PATIENTS AND METHODS: Twenty-four participants with clinically diagnosed as OLP were enrolled in this study. We separated the patients in 2 groups, 12 patients in group A were treated by intralesional PRP every two weeks for 2 months or stopped if healing occurred earlier. Group B (12 patients) treated by intralesional Triamcinolone Acetonide (TA) (20 mg) every two weeks for 2 months or may be less if healing occurred earlier. The response of OLP lesions to treatment was evaluated by reduction of lesional areas, REU scores, and NRS scores. The patients with complete response (CR; 80%-100% reduction in the lesion area) were followed for 3 months biweekly.

RESULTS: There was a statistically significant decrease in REU and pain score in both groups after treatment compared to before. There was a statistically increase in frequency of side effects among patients received PRP especially pain compared to those treated by steroid. Also, recurrence of the disease after treatment during follow-up for 3 months was more significant among patients treated by PRP.

CONCLUSION: Intralesional PRP is a good and safe modality for treatment of OLP and intralesional TA. However, there were some side effects and recurrence of disease after follow-up for three months in patients treated by PRP more than those treated by TA.

PMID:36718838 | DOI:10.1111/jocd.15622

J Cosmet Dermatol. 2023 Jan 31. doi: 10.1111/jocd.15634. Online ahead of print.

ABSTRACT

BACKGROUND: Consequently, the management of post burn hypertrophic scars and keloid in children are a great challenge for the physicians, parents, and children themselves.

PURPOSE OF THE STUDY: To assess the efficacy and safety of treating hypertrophic and keloid scars with botulinum toxins injections.

PATIENTS AND METHODS: This is a randomized intra-patient comparative study was conducted on 15 children with post burn hypertrophic and keloid scars. Children were randomized to receive Intralesional injection of botulinum toxins on one part of the hypertrophic scar/keloid where the other part was left as a control. The assessment of clinical improvement was measured by the Vancouver scar scale (VSS) and by skin analysis camera system. Sessions were performed every month for 6 months.

RESULTS: Clinical and statistical dramatic improvement in the vascularity, pliability, and height of the lesions which have been injected with neuronox. Evaluation of the lesions by the Antera camera has proven marked changes in the vascularity and height. There was no correlations between Vancouver score improvement and variables such as the age, sex, skin type, and duration and lesion type.

CONCLUSIONS: The botulinum toxins proved its efficacy and safety in treatment of hypertrophic scars and keloid in children. It improved the associated itching and pain. Moreover it improves the pliability, erythema, and thickness of the scars.

PMID:36718819 | DOI:10.1111/jocd.15634

Interact J Med Res. 2023 Jan 31. doi: 10.2196/40883. Online ahead of print.

ABSTRACT

BACKGROUND: Despite significant improvement in the last decade, road trauma remains a significant contributor to deaths in Vietnam. The COVID-19 pandemic necessitated public health measures which had an unforeseen benefit on road trauma in high income countries. We investigate if this reduction was also seen in a low to middle income country, Vietnam.

OBJECTIVE: Our aim was to investigate how the COVID-19 pandemic, and the government policies to address it, impacted on road trauma fatalities in Vietnam. We also compared this impact with other government policies intended to road trauma in the preceding 14 years (2007 to 2020).

METHODS: COVID-19 data was extracted from the Vietnamese Ministry of Health (MoH) database. Road traffic deaths from 2007 to 2021 were derived from the Vietnamese General Statistical Office (GSO). We used Stata software 17 for statistical analysis. Poisson regression modelling, with the logarithm of the national population of Vietnam of each year included as an offset, was used to estimate trends in rates of road fatalities from the annual national mortality data for the period 2007-2021. The actual change in road traffic mortality in 2021 was compared with calculated figures to demonstrate the effect of COVID-19 on road trauma fatalities. We also compared this impact with other government road toll reduction policies for 14 years (2007 to 2020).

RESULTS: Between 2007 and 2020 the number of annual road traffic deaths had more than halved from 15.3 to 7.0 per 100,000, an average reduction of 5.4% per annum. We estimated that the road traffic mortality rate declined by 12.1% (95% CI 8.9 to 15.3%) in 2021 relative to trend. The actual number of road trauma deaths fell by 16.4%. This reduction was largely seen from August to October 2021 when lockdown and social distancing were in force.

CONCLUSIONS: In 2021, the road traffic death reduction in Vietnam was 3 times greater than the trend over the preceding 14 years. The public heath response to the COVID-19 pandemic in Vietnam was associated with a third of this reduction. It can thus be reasonably concluded that government policies to address the COVID-19 pandemic resulted in a 4.3% decrease of road traffic deaths in 2021. This has been observed in High-Income Countries but was demonstrated by us for the first time in a Low- and Middle-Income Country.

PMID:36718815 | DOI:10.2196/40883

Q J Exp Psychol (Hove). 2023 Jan 31:17470218231155897. doi: 10.1177/17470218231155897. Online ahead of print.

ABSTRACT

The Dual strategy model suggests that people can either use a Statistical or a Counterexample reasoning strategy, which reflects two qualitatively different way of processing information. This model has been shown to capture individual differences in a wide array of tasks, such as contingency learning. Here, we examined whether this extends to individual differences in the interpretation of contingency information where effects are ambiguous. Previous studies, using perceptually complex stimuli, have shown that the way which participants interpret ambiguous effects predicts causal judgments, In two studies, we attempted to replicate this effect using a small number of clearly identifiable cues. Results show that interpretation of ambiguous effects as effect present is related to final contingency judgments. In addition, results showed that Statistical reasoners had a stronger tendency to interpret ambiguous effects as effect present than Counterexample reasoners, which mediates the difference in contingency judgements.

PMID:36718805 | DOI:10.1177/17470218231155897