Category: Nevin Manimala

Otolaryngol Head Neck Surg. 2023 Mar 5. doi: 10.1002/ohn.162. Online ahead of print.

ABSTRACT

OBJECTIVE: Describe the effect that cochlear implantation (CI) has on audiometric outcomes and quality of life (QOL) in patients with single-sided deafness (SSD).

STUDY DESIGN: Retrospective case review.

SETTING: Tertiary university hospital system.

METHODS: Preoperative and postoperative AzBio performance and Cochlear Implant Quality of Life-35 (CIQOL-35) Profile scores in CI patients with SSD were compared, and postoperative measures were compared to those from CI patients without SSD.

RESULTS: Seventeen patients with unilateral CI and contralateral unaided pure-tone averages ≤30 dB were included. The median age was 60.2 (interquartile range [IQR], 50.9-64.9 years), and 7/17 (41%) were women. Median daily use was 8.2 hour (IQR, 5.4-11.9 h). The median preoperative AzBio quiet score in the ear to be implanted was 3% (IQR, 0%-6%). After a median follow-up of 12.0 months, the median postoperative AzBio quiet score was 76% (IQR, 47%-86%) (p < .01). SSD subjects demonstrated statistically significant improvements in median scores on the following CIQOL-35 subdomains following implantation: Entertainment (17 preoperatively vs 21 postoperatively), Listening Effort (12 vs 14), Social (17 vs 22), and Global (28 vs 35; p < .05). SSD patients achieved equal or higher postoperative CIQOL-35 scores in most subdomains (6/7) compared to an age-matched group of non-SSD CI recipients who underwent unilaterally (N = 19) or sequential (N = 6) implantation.

CONCLUSION: SSD CI patients not only demonstrate significant improvements in speech perception testing in the implanted ear but also exhibit improvement in multiple QOL subdomains on the CIQOL-35, the only validated cochlear implant QOL instrument.

PMID:36871181 | DOI:10.1002/ohn.162

Dig Dis Sci. 2023 Mar 4. doi: 10.1007/s10620-023-07885-6. Online ahead of print.

ABSTRACT

OBJECTIVES: Colorectal cancer (CRC) is the third most common malignancy in the US. Several factors are associated with increased/decreased CRC risk and often linked to adenomatous colorectal polyps (CRP). Recent studies suggest a lower risk of neoplastic lesions among irritable bowel syndrome (IBS) patients. We aimed to systematically assess the occurrence of CRC and CRP in IBS patients.

METHODS: Searches of the Medline, Cochrane, and EMBASE databases were performed, blindly and independently, by two investigators. Studies of CRC or CRP incidence in IBS patients (diagnosed by Rome or other symptom-based criteria) were eligible for inclusion. CRC and CRP effect estimates were pooled in meta-analyses using random models.

RESULTS: Of 4941 non-duplicate studies, 14 were included, comprising 654,764 IBS patients and 2,277,195 controls in 8 cohort studies, and 26,641 IBS patients and 87,803 controls in 6 cross-sectional studies. Pooled analysis revealed a significantly decreased prevalence of CRP in IBS subjects vs. controls, with a pooled odds ratio (OR) of 0.29 (95% CI (0.15, 0.54)). There was significant heterogeneity between studies (I² = 96%, p < 0.01). This finding persisted when studies which did not report pre-cancerous polyps separately were excluded (OR 0.23, 95% CI (0.15, 0.35), I² = 85%, p < 0.01). CRC prevalence was lower in IBS subjects, but this did not reach statistical significance (OR 0.40, 95% CI (0.09, 1.77]).

CONCLUSION: Our analyses reveal a decreased incidence of colorectal polyps in IBS, although CRC did not reach significance. Mechanistic studies with detailed genotypic analysis and clinical phenotyping are needed to better elucidate the potentially protective effect of IBS on CRC development.

PMID:36871131 | DOI:10.1007/s10620-023-07885-6

Aging Clin Exp Res. 2023 Mar 5. doi: 10.1007/s40520-023-02363-5. Online ahead of print.

ABSTRACT

OBJECTIVE: This study aims to accurately evaluate the cardiac structure and function of the frail population in elderly patients with normal ejection fraction (EF) using the 3D volume quantification and speckle tracking of echocardiography, to explore the correlation between frailty and cardiac structure and function.

METHODS: A total of 350 elderly aged 65 and above in-patients, excluding those with congenital heart disease, cardiomyopathy, and severe valvular heart disease, were included in the study. Patients were divided into non-frail, pre-frail, and frail group. Echocardiography techniques including speckle tracking and 3D volume quantification, were used to analyze the cardiac structure and function of the study subjects. Comparative analysis was statistically significant if P < 0.05.

RESULTS: The cardiac structure of the frail group was different compared with non-frail patients, the frail group demonstrated increased left ventricular myocardial mass index (LVMI), but decreased stroke volume. Cardiac function was also impaired in the frail group: reservoir strain and conduit strain of left atrium, strain of right ventricular (RV) free wall, strain of RV septum, 3D EF of RV, and global longitudinal strain of LV were significantly decreased. Frailty was significantly and independently associated with LV hypertrophy (OR 1.889; 95% CI 1.240,2.880; P = 0.003), LV diastolic dysfunction (OR 1.496; 95% CI 1.016,2.203; P = 0.041), left ventricular global longitudinal strain (LVGLS) reduction (OR 1.697; 95% CI 1.192, 2.416; P = 0.003), and reduced RV systolic function (OR 2.200; 95% CI 1.017, 4.759; P = 0.045).

CONCLUSION: Frailty is closely associated with several heart structural and functional alterations, which not only manifested as LV hypertrophy and reduced LV systolic function, but also decreased LV diastolic function, RV systolic function, and left atrial systolic function. Frailty is an independent risk factor for LV hypertrophy, LV diastolic dysfunction, LVGLS reduction, and reduced RV systolic function.

TRIAL REGISTRATION NUMBER: ChiCTR2000033419. Date of registration: May 31, 2020.

PMID:36871112 | DOI:10.1007/s40520-023-02363-5

Exp Brain Res. 2023 Mar 4. doi: 10.1007/s00221-023-06570-4. Online ahead of print.

ABSTRACT

This effort seeks to further assess human perception of self-motion by quantifying and comparing earth-vertical rotational vestibular perceptual thresholds about the yaw, roll, and pitch axes. Early seminal works (Benson Aviat Space Environ Med 60:205-213, 1989) quantified thresholds for yaw, roll, and pitch rotations, using single-cycle sinusoids in angular acceleration with a frequency of 0.3 Hz (3.33 s motion duration) and found yaw thresholds to be significantly lower than roll and pitch thresholds (1.58-1.20 deg/s vs. 2.07 deg/s and 2.04 deg/s, respectively). Our current effort uses modern methods and definitions to reassess if rotational thresholds differ between these three axes of rotation in ten human subjects at 0.3 Hz and additionally across a range of frequencies: 0.1 Hz, 0.3 Hz, and 0.5 Hz. In contrast to the established findings of Benson et al., no statistically significant differences were found between the three rotational axes at 0.3 Hz. Further, no statistically significant differences were found at any of these frequencies. Instead, a consistent pattern was found for yaw, pitch, and roll of increasing thresholds with decreasing rotational frequency, consistent with the brain employing high-pass filter mechanisms for decision-making. We also fill a gap in the literature by extending the quantification of pitch rotation thresholds to 0.1 Hz. Finally, we assessed inter-individual trends between these three frequencies and across all three axes of rotation. In thoroughly considering methodological and other differences between the current and previous studies, we conclude yaw rotation thresholds do not differ from those in roll or pitch.

PMID:36871088 | DOI:10.1007/s00221-023-06570-4

Sci Rep. 2023 Mar 4;13(1):3646. doi: 10.1038/s41598-023-30606-y.

ABSTRACT

Adding hooked industrial steel fibers (ISF) to concrete boosts its tensile and flexural strength. However, the understanding of ISF’s influence on the compressive strength (CS) behavior of concrete is still questioned by the scientific society. The presented paper aims to use machine learning (ML) and deep learning (DL) algorithms to predict the CS of steel fiber reinforced concrete (SFRC) incorporating hooked ISF based on the data collected from the open literature. Accordingly, 176 sets of data are collected from different journals and conference papers. Based upon the initial sensitivity analysis, the most influential parameters like water-to-cement (W/C) ratio and content of fine aggregates (FA) tend to decrease the CS of SFRC. Meanwhile, the CS of SFRC could be enhanced by increasing the amount of superplasticizer (SP), fly ash, and cement (C). The least contributing factors include the maximum size of aggregates (D_max) and the length-to-diameter ratio of hooked ISFs (L/D_ISF). Several statistical parameters are also used as metrics to evaluate the performance of implemented models, such as coefficient of determination (R²), mean absolute error (MAE), and mean of squared error (MSE). Among different ML algorithms, convolutional neural network (CNN) with R² = 0.928, RMSE = 5.043, and MAE = 3.833 shows higher accuracy. On the other hand, K-nearest neighbor (KNN) algorithm with R² = 0.881, RMSE = 6.477, and MAE = 4.648 results in the weakest performance.

PMID:36871074 | DOI:10.1038/s41598-023-30606-y

Br J Cancer. 2023 Mar 4. doi: 10.1038/s41416-023-02212-2. Online ahead of print.

ABSTRACT

BACKGROUND: This open-label, multicentre, phase II/III trial assessed the noninferiority of trifluridine/tipiracil (FTD/TPI) plus bevacizumab vs. fluoropyrimidine and irinotecan plus bevacizumab (control) as second-line treatment for metastatic colorectal cancer (mCRC).

METHODS: Patients were randomised (1:1) to receive FTD/TPI (35 mg/m² twice daily, days 1-5 and days 8-12, 28-day cycle) plus bevacizumab (5 mg/kg, days 1 and 15) or control. The primary endpoint was overall survival (OS). The noninferiority margin of the hazard ratio (HR) was set to 1.33.

RESULTS: Overall, 397 patients were enrolled. Baseline characteristics were similar between the groups. Median OS was 14.8 vs. 18.1 months (FTD/TPI plus bevacizumab vs. control; HR 1.38; 95% confidence interval [CI] 0.99-1.93; P_{noninferiority} = 0.5920). In patients with a baseline sum of the diameter of target lesions of <60 mm (n = 216, post hoc analyses), the adjusted median OS was similar between groups (FTD/TPI plus bevacizumab vs. control, 21.4 vs. 20.7 months; HR 0.92; 95% CI 0.55-1.55). Grade ≥3 adverse events (FTD/TPI plus bevacizumab vs. control) included neutropenia (65.8% vs. 41.6%) and diarrhoea (1.5% vs. 7.1%).

CONCLUSIONS: FTD/TPI plus bevacizumab did not demonstrate noninferiority to fluoropyrimidine and irinotecan plus bevacizumab as second-line treatment for mCRC.

CLINICAL TRIAL REGISTRATION: JapicCTI-173618, jRCTs031180122.

PMID:36871043 | DOI:10.1038/s41416-023-02212-2

Sci Rep. 2023 Mar 4;13(1):3649. doi: 10.1038/s41598-023-30729-2.

ABSTRACT

Island nations may have potential long-term survival value for humanity in global catastrophes such as sun-blocking catastrophes from nuclear winter and large magnitude volcanic eruptions. One way to explore this issue further is to understand the impact on islands after the largest historically observed volcanic eruption: that of Mt Tambora in 1815. For each of the 31 large, populated islands selected, we conducted literature searches for relevant historical and palaeoclimate studies. We also analysed results from a reconstruction (EKF400v2), which uses atmospheric-only general circulation model simulations with assimilated observational and proxy data. From the literature review, there was widespread evidence for weather/climate anomalies in 1815-1817 for these islands (29/29 for those with data). But missing data was an issue for other dimensions such as impaired food production (seen in 8 islands out of only 12 with data). Based on the EKF400v2 reconstruction for temperature anomalies (compared to the relatively “non-volcanic” reference period of 1779 to 1808), the islands had lower temperature anomalies in the 1815-1818 period than latitudinally equivalent continental sites (at 100 km and 1000 km inland). This was statistically significant for the great majority of the comparisons for group analyses by hemisphere, oceans, and temperate/tropical zone. When considering just the islands, all but four showed statistically anomalous temperature reductions in the 1816-1817 period (for most p < 0.00001). In the peak impact year of 1816, the lowest anomalies were seen for islands in the Southern Hemisphere (p < 0.0001), the Indian Ocean (p < 0.0001), and in the tropics and subtropics of the Southern Hemisphere (p = 0.0057). In conclusion, the findings of both the literature review and reconstruction simulations suggest climatic impacts of the Tambora eruption for nearly all these 31 large islands, albeit less than for continental sites. Islands with the smallest temperature anomalies were in the Southern Hemisphere, in particular the Indian Ocean and the tropics and subtropics of the Southern Hemisphere.

PMID:36871039 | DOI:10.1038/s41598-023-30729-2

Pediatr Res. 2023 Mar 4. doi: 10.1038/s41390-023-02539-9. Online ahead of print.

ABSTRACT

BACKGROUND: Cow’s Milk-related Symptom Score (CoMiSS) is an awareness tool to recognize cow’s milk allergy (CMA) symptoms in infants. We aimed to assess the best cut-off point of CoMiSS in our country and investigate other parameters suggested to raise the strength of CoMiSS in CMA diagnosis.

METHODS: We enrolled 100 infants with CMA-suggestive symptoms with documentation of CoMiSS initially and 4 weeks after cow milk-free diet (CMFD) followed by an open food challenge (OFC) test. Infants with symptom recurrence upon challenge were diagnosed with confirmed CMA.

RESULTS: Initial mean CoMiSS was 15.76 ± 5.29, being higher in the confirmed CMA group (84% of infants). Following CMFD, median CoMiSS significantly reduced to 1.5 in the confirmed CMA group compared to 6.5 in the negative group. Receiver operation characteristic (ROC) curve identified a CoMiSS score of ≥12 as the best cut-off value with 76.19% sensitivity, 62.50% specificity and overall accuracy of 74.00%. Mucoid stool, bloody stool and faltering growth were reported in 80, 41 and 52% of confirmed CMA infants, respectively, with considerable improvement following CMFD.

CONCLUSIONS: Our study revealed a CoMiSS score of ≥12 to be the best cut-off point. However, CoMiSS cannot be used alone for accurate diagnosis of CMA.

IMPACT: CoMiSS ≥12 can predict a positive response to CMFD; nevertheless, CoMiSS is a good awareness tool and cannot be regarded as a stand-alone CMA diagnostic test. CoMiSS reduction following CMFD was predictive of a reaction to OFC to diagnose CMA as well as for monitoring symptom improvement. Symptoms commonly associated with CMA as mucoid stool, bloody stool, marked abdominal distention not responding to medical treatment and faltering growth, in addition to their improvements in response to CMA are suggested parameters to be added to CoMiSS to improve its accuracy.

PMID:36871030 | DOI:10.1038/s41390-023-02539-9

Sci Rep. 2023 Mar 4;13(1):3670. doi: 10.1038/s41598-023-30634-8.

ABSTRACT

This study aimed to synthesize an amidoximated Luffa cylindrica (AO-LC) bioadsorbent, and evaluate its efficiency in the adsorption of heavy metals from the aqueous solutions. For this purpose, NaOH solution was used to alkaline treatment of Luffa cylindrica (LC) fibers. The silane modification of LC was performed using 3-(trimethoxysilyl)propyl methacrylate (MPS). Polyacrylonitrile (PAN)/LC biocomposite (PAN-LC) was synthesized by PAN grafting onto the MPS-modified LC (MPS-LC). Finally, the AO-LC was obtained by the amidoximation of PAN-LC. The chemical structures, morphology, and thermal properties of biocomposites were characterized by the infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and field emission scanning electron microscopy. The results showed a successful grafting of MPS and PAN on the surface of LC. The order of heavy metals adsorption on AO-LC was: Pb²⁺ > Ag⁺ > Cu²⁺ > Cd²⁺ > Co²⁺ > Ni²⁺. The effects of operational parameters on the Pb²⁺ adsorption were studied using Taguchi experimental design method. Statistical analysis of the results showed that the initial Pb²⁺ concentration and the bioadsorbent dosage significantly affect the adsorption efficiency. The adsorption capacity and removal percentage of Pb²⁺ ions were obtained as 18.88 mg/g and 99.07%, respectively. The Langmuir isotherm and Pseudo-second order kinetics models were found to be better compatible with experimental data as a consequence of the isotherm and kinetics analysis.

PMID:36871018 | DOI:10.1038/s41598-023-30634-8

Lipids Health Dis. 2023 Mar 4;22(1):32. doi: 10.1186/s12944-023-01783-6.

ABSTRACT

BACKGROUND AND AIMS: The effect of body fat deposition on the kidney has received increasing attention. The Chinese visceral adiposity index (CVAI) is an important indicator of recent research. The purpose of this study was to explore the predictive value of CVAI and other organ obesity indicators in predicting CKD in Chinese residents.

METHODS: A retrospective cross-sectional study of 5355 subjects was performed. First, the study utilized locally estimated scatterplot smoothing to describe the dose-response relationship between the estimated glomerular filtration rate (eGFR) and CVAI. The L1-penalized least absolute shrinkage and selection operator (LASSO) regression algorithm was used for covariation screening, and the correlation between CVAI and eGFR was quantified using multiple logistic regression. At the same time, the diagnostic efficiency of CVAI and other obesity indicators was evaluated by ROC curve analysis.

RESULTS: CVAI and eGFR were negatively correlated. Using group one as the control, an odds ratio (OR) was calculated to quantify CVAI quartiles (ORs of Q2, Q3, and Q4 were 2.21, 2.99, and 4.42, respectively; P for trend < 0.001). CVAI had the maximum area under the ROC curve compared with other obesity indicators, especially in the female population (AUC: 0.74, 95% CI: 0.71-0.76).

CONCLUSIONS: CVAI is closely linked to renal function decline and has certain reference value for the screening of CKD patients, particularly in women.

PMID:36871015 | DOI:10.1186/s12944-023-01783-6