Category: Statistics

Menopause. 2024 Jan 9. doi: 10.1097/GME.0000000000002301. Online ahead of print.

ABSTRACT

IMPORTANCE: Menopause impacts the quality of life for women, with symptoms varying from hot flashes to night disturbances. When menopausal hormonal therapy is contraindicated or women refuse menopausal hormonal therapy, many consider alternatives such as pollen extract for treating vasomotor symptoms.

OBJECTIVE: This meta-analysis focuses on the impact of using purified pollen extract as a treatment option to reduce vasomotor symptoms in women, specifically focusing on symptoms such as hot flashes, night disturbances, myalgias, and depression.

EVIDENCE REVIEW: A comprehensive literature search was conducted using the following Boolean search string “women OR females” AND “purified pollen OR pollen extract OR cytoplasmic pollen OR Bonafide OR Femal OR Estroven OR Serelys” AND “menopausal symptoms OR vasomotor symptoms OR hot flashes OR night sweats OR sleep disturbance.” Publications in English from 2003 to the present were included. To assess the risk of bias, authors used the Cochrane Risk-of-Bias 2 for a randomized controlled trial and Risk-of-Bias in Non-Randomized Studies of Interventions (ROBINS-I) for observational studies. Using ReviewManager, a Der Simonian-Laird random-effects model meta-analysis was conducted to determine the standardized mean differences (SMDs) in the outcomes for each study.

FINDINGS: Five articles were retained: one randomized controlled trial and four observational studies (N = 420). An overall decrease in scores from the baseline of studies compared with a 3-month follow-up after purified cytoplasm of pollen (PCP) treatment was recognized when compiling the data. Overall, there was significant improvement across all outcomes at 3 months: hot flashes demonstrated an overall improvement in SMD of -1.66 (P < 0.00001), night disturbance scores were improved with an SMD of -1.10 (P < 0.0001), depression scores were improved with an SMD of -1.31 (P < 0.0001), and myalgia had an improvement in SMD of -0.40 (P < 0.00001). When controlled studies were pooled for meta-analysis, outcomes, however, were no longer statistically significant.

CONCLUSIONS AND RELEVANCE: Evaluating the risk-to-benefit ratio of alternative therapies, such as PCP extract, is important to care for women who cannot take traditional vasomotor symptom therapies. Pooled data from controlled studies evaluating PCP extract suggest that vasomotor symptom improvements seen in noncontrolled studies may have been due to the placebo effect; however, its use was not associated with significant adverse effects.

PMID:38194609 | DOI:10.1097/GME.0000000000002301

Int J Cancer. 2024 Jan 9. doi: 10.1002/ijc.34829. Online ahead of print.

ABSTRACT

Esophageal squamous cell carcinoma (ESCC) is the second most common cancer in Malawi. Risk factors for this cancer in Malawi are poorly understood. Poor oral health has previously been linked to increased ESCC risk in other high-incidence regions, including parts of Eastern and Southern Africa. We assessed the relationship between oral health and ESCC risk in a sex, age and location frequency-matched case-control study based at two hospitals in Lilongwe, Malawi from 2017 to 2020. Trained interviewers used a structured questionnaire and direct observation to collect data on demographics; behaviors; oral hygiene habits; the sum of decayed, missing or filled teeth (DMFT score); oral mucosa status; lip depigmentation and dental fluorosis via a visual scale. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI), adjusted for known and suspected ESCC risk factors. During the study period, 300 cases and 300 controls were enrolled. Subjects in the highest tertile of DMFT score (≥7) had an increased risk of ESCC with an adjusted OR of 1.96 (95% CI: 1.16-3.36) compared to those with a DMFT score of 0. Severe dental fluorosis was associated with a statistically nonsignificant increased risk of ESCC (adjusted OR = 2.24, 95% CI: 0.97-5.49) compared to individuals with no fluorosis. Associations with oral mucosa status, lip depigmentation and toothbrushing method and frequency were mostly null or uncertain. Poor oral health, indicated by a higher DMFT score, was associated with increased ESCC risk in Malawi. Dental fluorosis is another possible risk factor in this population, but further evaluation is necessary to clarify any effects of fluorosis on ESCC risk.

PMID:38194606 | DOI:10.1002/ijc.34829

J Bone Joint Surg Am. 2024 Jan 9. doi: 10.2106/JBJS.23.00995. Online ahead of print.

ABSTRACT

BACKGROUND: Historically, orthopaedic surgery has had low female representation, with <6% of practicing surgeons identifying as female. Although prior literature has illustrated gender disparities in first and last authorship as well as changes in gender representation over time, less attention has been paid to middle authorship. We hypothesized that trends in female authorship would reflect increasing female participation in orthopaedic surgery and orthopaedic subspecialties coinciding with an overall increase in female authorship.

METHODS: Bibliometric information from articles published between 2011 and 2021 in 6 orthopaedic journals was extracted with use of the Web of Science. Collected data included author order, author names, affiliation, and corresponding author address. A gender was assigned with the use of Genderize.io, which is validated software, on the basis of author first name. Statistical analysis was performed with use of an analysis of variance for each journal, and linear regression was performed to determine trends, controlling for year.

RESULTS: Among all included orthopaedic journals, female middle authorship increased by 5 percentage points, female first authorship increased by 4 percentage points, and female last authorship increased by 1 percentage point. Over the study period, the highest rate of female middle authorship (28%) was seen in the Journal of Pediatric Orthopaedics, whereas the lowest rate (16%) was seen in The Journal of Arthroplasty. We found that the 5 highest-producing female last authors were, on average, cited significantly less per publication than their male counterparts in all but 2 journals.

CONCLUSIONS: Gender gaps exist within orthopaedic surgery as well as within its body of literature. Although this study highlights areas of growth, it also promotes further inquiry into research productivity and the availability of opportunity within orthopaedic surgery as a whole. The increase in female middle authorship overall and in each journal demonstrates momentum for future growth for women in the field of orthopaedic surgery.

PMID:38194590 | DOI:10.2106/JBJS.23.00995

Plast Reconstr Surg. 2024 Jan 8. doi: 10.1097/PRS.0000000000011285. Online ahead of print.

ABSTRACT

Whereas 100% of Congressional legislators vote on healthcare policy, only a minority have a background in healthcare. A review of the participation of healthcare professionals (HCPs) in Congress, highlighting participation by surgeons, is critical to the future policy-making endeavors in healthcare. This article seeks to better understand the characteristics of HCPs that engage in advocacy and describe the trends in their representation in Congress, with commentary on participation by surgeons and its impact on current health advocacy efforts.A search of Congress.gov and the Biographical Directory of the United States Congress was performed to identify professional healthcare history for each Congressperson, followed by review of official campaign websites for health advocacy work. Statistical analysis was performed using IBM® SPSS® Statistics Software for changes in representation of healthcare professionals, physicians, and surgeons in Congress over time.While there has been increasing representation of HCPs in Congress in the last 25 years, surgeons have the lowest increase in Congressional membership. For healthcare reform to optimally address high costs, variable insurance coverage and reimbursement rates, and equal access to care, more physicians must make healthcare advocacy efforts an integral part of their careers. Incorporation of education in areas of healthcare advocacy and/or reform into undergraduate and graduate medical education curricula may help address deficiencies in knowledge of current healthcare-related events to further encourage involvement in healthcare legislation.

PMID:38194586 | DOI:10.1097/PRS.0000000000011285

J Int Med Res. 2024 Jan;52(1):3000605231223038. doi: 10.1177/03000605231223038.

ABSTRACT

OBJECTIVE: To determine the distribution of ABO and Rh (D) blood group phenotypes among blood donors.

METHODS: This retrospective cross-sectional study enrolled blood donors whose socio-demographic and blood group phenotype data were collected from blood bank donor records. Descriptive statistics were used to summarise the number and percentage distribution of categorical variables. To determine if the distributions of the ABO and Rh phenotypes differed, a chi-square test was employed.

RESULTS: Of 14,887 blood donors with a median age of 20 years (interquartile range = 18-30 years), 72.8% were males, and young donors (age range = 18-24 years) accounted for 61.7%. Group O (45.6%) was the most prevalent ABO blood phenotype, followed by A (29.5%), B (20.2%), and AB (4.7%). The dominant blood group was O positive (42.4%), followed by A positive (27.4%), B positive (18.9%), AB positive (4.3%), O negative (3.2%), A negative (2.1%), B negative (1.3%), and AB negative (0.4%). The overall Rh (D)-negative distribution rate was 7.0%.

CONCLUSION: This study showed that blood group O was the most common ABO phenotype, followed by A, B, and AB. Overall, 93.0% of the donors were Rh (D)-positive. These findings may help guide blood transfusion programmes.

PMID:38194583 | DOI:10.1177/03000605231223038

Opt Lett. 2024 Jan 15;49(2):326-329. doi: 10.1364/OL.509166.

ABSTRACT

We present and experimentally demonstrate a new, to the best of our knowledge, technique to quantitatively measure coherence-polarization (BCP) matrix with correlations of only two Stokes fluctuations. The BCP matrix is a square matrix with four elements that involves two-point correlations among orthogonal polarization components. A theoretical framework of the technique is developed, and its viability is demonstrated by a proof of principle experiment. Experimental tests and measurement of the elements of the BCP matrix of statistically stationary beams are demonstrated.

PMID:38194560 | DOI:10.1364/OL.509166

Diabetes Care. 2024 Jan 9:dc231332. doi: 10.2337/dc23-1332. Online ahead of print.

ABSTRACT

OBJECTIVE: In Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) (5,047 participants, mean follow-up 5.0 years), differences in glycemic control were demonstrated over time among four randomized therapies added to metformin. Weight gain and hypoglycemia are also important outcomes for people with type 2 diabetes. We compared the effects of the four randomized GRADE medications on a composite outcome incorporating glycemic deterioration, weight gain, and hypoglycemia.

RESEARCH DESIGN AND METHODS: The composite outcome was time to first occurrence of any of the following: HbA1c >7.5%, confirmed; ≥5% weight gain; or severe or recurrent nonsevere hypoglycemia. Secondary analyses included examination of individual components of the composite outcome, subgroup effects and potential mediators, and treatment satisfaction. Cumulative incidence was estimated with the Kaplan-Meier estimator. Cox proportional hazards models were used to assess pairwise group differences in risk of an outcome.

RESULTS: Risk of reaching the composite outcome (events per 100 participants per treatment year [PTYs]) was lowest with liraglutide (19 per 100 PTYs) followed by sitagliptin (26 per 100 PTYs), glargine (29 per 100 PTYs), and glimepiride (40 per 100 PTYs); all pairwise comparisons were statistically significant. The order was the same for risk of weight gain and hypoglycemia, but risk of glycemic deterioration was lowest with glargine, followed by liraglutide, glimepiride, and sitagliptin. No significant heterogeneity in risk of composite outcome was detected across prespecified covariates. Participants who reached the composite outcome had modestly but significantly lower treatment satisfaction.

CONCLUSIONS: Among participants treated with common second-line drug classes for type 2 diabetes, the liraglutide group had the lowest and glimepiride the highest risk of reaching a composite outcome encompassing glycemic deterioration, weight gain, and hypoglycemia. These findings may inform decision-making regarding type 2 diabetes therapy.

PMID:38194519 | DOI:10.2337/dc23-1332

ACS Chem Neurosci. 2024 Jan 9. doi: 10.1021/acschemneuro.3c00611. Online ahead of print.

ABSTRACT

Some pathological conditions affecting the human body can also disrupt metabolic pathways and thus alter the overall metabolic profile. Knowledge of metabolic disturbances in specific diseases could thus enable the differential diagnosis of otherwise similar conditions. This work therefore aimed to comprehensively characterize changes in tryptophan metabolism in selected neurodegenerative diseases. Levels of 18 tryptophan-related neuroactive substances were determined by high throughput and sensitive ultrahigh-performance liquid chromatography-tandem mass spectrometry in time-linked blood serum and cerebrospinal fluid samples from 100 age-matched participants belonging to five cohorts: healthy volunteers (n = 21) and patients with Lewy body disease (Parkinson’s disease and dementia with Lewy bodies; n = 31), four-repeat tauopathy (progressive supranuclear palsy and corticobasal syndrome; n = 10), multiple system atrophy (n = 13), and Alzheimer’s disease (n = 25). Although these conditions have different pathologies and clinical symptoms, the discovery of new biomarkers is still important. The most statistically significant differences (with p-values of ≤0.05 to ≤0.0001) between the study cohorts were observed for three tryptophan metabolites: l-kynurenine in cerebrospinal fluid and 3-hydroxy-l-kynurenine and 5-hydroxy-l-tryptophan in blood serum. This led to the discovery of distinctive correlation patterns between the profiled cerebrospinal fluid and serum metabolites that could provide a basis for the differential diagnosis of neurodegenerative tauopathies and synucleinopathies. However, further large-scale studies are needed to determine the direct involvement of these metabolites in the studied neuropathologies, their response to medication, and their potential therapeutic relevance.

PMID:38194490 | DOI:10.1021/acschemneuro.3c00611

Clin Exp Optom. 2024 Jan 9:1-6. doi: 10.1080/08164622.2024.2301983. Online ahead of print.

ABSTRACT

CLINICAL RELEVANCE: Due to the long-time that wind musicians spend playing their instruments, it is important to investigate if intraocular pressure could be affected by this activity.

BACKGROUND: To assess the intraocular pressure fluctuations and fluctuations affecting factors in professional wind musicians while playing different tones.

METHODS: Thirty professional wind musicians (23.0 ± 3.20 years) were recruited from the Professional Music College of A Coruña. A questionnaire about environmental/demographic factors was given to participants. Intraocular pressure was measured four times by ICare IC100 tonometer: before, during low and high-pitched tones, and immediately after stopping playing the wind instrument.

RESULTS: Pairwise comparison revealed statistical differences between measurement points (Sidak, all p ≤ 0.019), except between before playing and while playing low-pitched tones (Sidak, p = 1.000). Intraocular pressure increases during high pitch playing and decreases after stopping playing. No significant differences in intraocular pressure fluctuation were reported between physically active (>2 days/week) and non-physically active participants (Unpaired t-test, p = 0.680). All intraocular pressure values were positively correlated (Pearson’s correlation, all r ≥ 0.505, p ≤ 0.004). Intraocular pressure fluctuations were negatively correlated with musical playing years (Pearson’s correlation, r = – 0.396, p = 0.030). There were no significant correlations among intraocular pressure fluctuation and gender, age, weight, height, or daily time playing (Pearson’s correlation, all p ≥ 0.058).

CONCLUSION: Professional wind musicians suffer intraocular pressure peaks while playing high-pitched tones; therefore, ocular fundus evaluation and visual campimetry should be performed as routine tests in the visual exam of this population.

PMID:38194485 | DOI:10.1080/08164622.2024.2301983

PLoS One. 2024 Jan 9;19(1):e0292669. doi: 10.1371/journal.pone.0292669. eCollection 2024.

ABSTRACT

Although CO2 field-flooding was first used during cardiac surgery more than 60 years ago, its efficacy is still disputed. The invisible nature of the gas and the difficulty in determining the “safe” quantity to protect the patient are two of the main obstacles to overcome for its validation. Moreover, CO2 concentration in the chest cavity is highly sensitive to procedural aspects, such suction and hand movements. Based on our review of the existing literature, we identified four major factors that influence the intra-cavity CO2 concentration during open-heart surgery: type of delivery device (diffuser), delivery CO2 flow rate, diffuser position around the wound cavity, and its orientation inside the cavity. In this initial study, only steady state conditions were considered to establish a basic understanding on the effect of the four above-mentioned factors. Transient factors, such as suction or hand movements, will be reported separately.

PMID:38194426 | DOI:10.1371/journal.pone.0292669