Tag: nevin manimala

Front Biosci (Landmark Ed). 2023 Jul 24;28(7):146. doi: 10.31083/j.fbl2807146.

ABSTRACT

BACKGROUND: High blood pressure is the main cause of cardiovascular diseases. Kidney damage is one of the most common organ secondary damage to hypertension. The study of hypertension gene polymorphisms is an important means of precision treatment of primary hypertension.

OBJECTIVES: The objective of this study was to explore the relationship between AGTR1 (c.1166 A>C) gene polymorphisms and hypertension combined with kidney damage, while exploring the relationship between codominant, dominant and recessive gene model and hypertension with kidney injury and the susceptibility of different genotypes to hypertension with kidney injury.

METHODS: The distribution of AGTR1 polymorphism in the AGTR1 in hypertensive patients (hypertension group, 292 patients) and hypertension with kidney injury patients (44 patients) were detected and compared by PCR-melting curve method.

RESULTS: The genotype distribution of hypertension and combined groups met Hardy-Weinberg equilibrium (p > 0.05); the distribution difference between the three genotypes was statistically significant (p < 0.05), the codominant, dominant and recessive distribution frequency of genotypes (p < 0.05), and no difference between A allele and C allele (p > 0.05).

CONCLUSIONS: Our study identified the relationship of AGTRA (c.1166 A>C) with hypertension combined with renal injury, and compared the susceptibility of different genetic models, which may provide novel targets for precision gene therapy of hypertension.

CLINICAL TRIAL REGISTRATION: URL: https://www.chictr.org.cn/indexEN.html; Unique identifier: ChiCTR2100051472.

PMID:37525908 | DOI:10.31083/j.fbl2807146

Cancer Med. 2023 Aug 1. doi: 10.1002/cam4.6390. Online ahead of print.

ABSTRACT

BACKGROUND: The role of endocrine therapy in the treatment of patients in a postmenopausal hormonal state and with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-positive advanced or metastatic breast cancer (AMBC) is unclear.

METHODS: We analyzed the data from 94 patients with ER-positive HER2-positive AMBC enrolled in the Safari study (UMIN000015168), a retrospective cohort study of 1072 ER-positive AMBC patients in a postmenopausal hormonal state who received fulvestrant 500 mg (F500): (1) to compare time to treatment failure (TTF) and overall survival (OS) by treatment group, and TTF by treatment line; (2) in patients who received endocrine therapy (including F500) or anti-HER2 therapy as initial systemic therapy before chemotherapy, to investigate relations between TTF for the first-line therapy or time to chemotherapy (TTC) and OS; (3) to investigate factors associated with OS.

RESULTS: The TTF was longer in the patients treated with F500 as first- or second-line therapy (n = 20) than in those who received later-line F500 therapy (n = 74) (6.6 vs. 3.7 months; HR, 1.98; p = 0.014). In the 59 patients who received endocrine therapy or anti-HER2 therapy as initial systemic therapy before chemotherapy, those with TTC ≥3 years had longer median OS than those with TTC <3 years (10.5 vs. 5.9 years; HR, 0.32; p = 0.001). Longer TTC was associated with prolonged OS.

CONCLUSIONS: In patients with ER-positive HER2-positive AMBC enrolled in the Safari study, TTF was longer in patients who received F500 as first- or second-line therapy. In patients who received chemotherapy-free initial systemic therapy, the prolonged OS in those with TTC ≥3 years suggests that this value may be a helpful cut-off for indicating clinical outcomes.

PMID:37525895 | DOI:10.1002/cam4.6390

Cleft Palate Craniofac J. 2023 Aug 1:10556656231190525. doi: 10.1177/10556656231190525. Online ahead of print.

ABSTRACT

OBJECTIVE: Studies evaluating the ability to diagnose and accurately predict the severity of micrognathia prenatally have yielded inconsistent results. This review aimed to evaluate reliability of prenatal diagnostic imaging in the diagnosis and characterization of micrognathia.

DESIGN: Systematic review and meta-analysis.

SETTING: Studies with a prenatal diagnosis of micrognathia via ultrasound with a confirmatory postnatal examination were included. Prenatal severity was defined with and without mandibular measurements. Extent of airway obstruction at birth was defined by level of intervention required. Meta-analyses of proportions and relative risk were performed.

PATIENTS: A total of 16 studies with 2753 neonates were included.

MAIN OUTCOME MEASURES: Primary outcome was the efficacy of characterizing the degree of micrognathia on prenatal imaging as it relates to respiratory obstruction at birth. Secondary outcome was the accuracy of prenatal diagnosis with the utilization of mandibular measurements versus without.

RESULTS: Performing meta-analysis of proportions, the proportion of missed prenatal diagnoses of micrognathia made without mandibular measurements was 11.62% (95%CI 2.58-25.94). Utilizing mandibular measurements, the proportion of cases missed were statistically lower (0.20% [95%CI 0.00-0.70]). Patients determined to have severe micrognathia by prenatal imaging did not have a statistically significant increase in risk for more severe respiratory obstruction at birth (RR 3.13 [95%CI 0.59-16.55], P = .180).

CONCLUSION: The proportion micrognathia cases missed when prenatal diagnosis was made without mandibular measurements was over 1 in 10, with mandibular measures improving accuracy. This study highlights the need for a uniform objective criterion to improve prenatal diagnosis and planning for postnatal care.

PMID:37525884 | DOI:10.1177/10556656231190525

Eur Oral Res. 2023 May 4;57(2):108-114. doi: 10.26650/eor.2023978293.

ABSTRACT

PURPOSE: The aim of this in-vitro study was to evaluate the effect of thermal changes to shear bond strength during the firing process of veneering porcelain on a zirconia framework.

MATERIALS AND METHODS: Single yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) framework ceramic (Kavo Dental GmbH) and three different types of veneering ceramics (IPS e.max Ceram, Vita VM9, and GC Initial Zr-FS) were used. One-hundred-twenty standard disc-shaped samples were prepared from zirconia blocks by using a CAD/CAM system (Kavo Everest). Four different cooling processes (maximum, 25°C/min, 50°C/min and 75°C/min) were applied to the veneering ceramics and the shear bond strength (SBS) test was performed. Ceramic surfaces were investigated by using scanning electron microscopeic (SEM). The possible occurrence of a t-m transformation of zirconia was evaluated by X-Ray Diffraction (XRD). Two-way analysis of variance, Bonferroni correction and paired comparisons were used for statistical analysis.

RESULTS: The main effects of veneering ceramics on shear bond strength were found to be significant (p=0.042). The mean shear bond strength values differ according to the cooling process (p<0.001). The monoclinic phase ratio increased in groups with fast cooling process.

CONCLUSION: The thermal changes during the firing process of veneering porcelain on a zirconia framework influenced the shear bond strength of the all-ceramic bilayered system. A slow cooling process provided higher strength for bilayer ceramic samples.

PMID:37525861 | PMC:PMC10387139 | DOI:10.26650/eor.2023978293

Eur Oral Res. 2023 May 4;57(2):90-95. doi: 10.26650/eor.20231083203.

ABSTRACT

PURPOSE: This study was to compare and evaluate the effect of home bleaching on the microhardness and flexural strength of microhybrid and nanohybrid composite resins.

MATERIALS AND METHODS: The study samples were prepared using a custom-made silicon rubber mold. For microhardness evaluation, 40 disc-shaped specimens (4mm*2mm) were prepared and divided into 4 groups: GROUP A (n=10): microhybrid (GC Solaire X, GC Corporation) control group, GROUP B (n=10) nanohybrid (Tetric N Ceram, Ivoclar Vivadent) control group, GROUP C (n=10): microhybrid bleaching group, GROUP D (n=10) nanohybrid bleaching group. For flexural strength evaluation, 40 bar shaped specimens (25mm*2mm*2mm) were prepared. They were divided into 4 groups, GROUP 1 (n=10): microhybrid control group, GROUP 2 (n=10) nanohybrid control group, GROUP 3 (n=10): microhybrid bleaching group, GROUP 4(n=10) nanohybrid bleaching group. All the control groups were placed in artificial saliva and bleaching groups were exposed to home bleaching agent for 14 days according to manufacturer’s instructions. The microhardness and flexural strength were evaluated for the respective specimens after 14 days and the data were statistically analyzed.

RESULTS: Home bleaching regimen decreased microhardness of both microhybrid and nanohybrid composites whereas there was no significant effect on the flexural strength. Nanohybrid composites showed greater microhardness values before and after bleaching.

CONCLUSION: Bleaching agents, irrespective of their concentration can decrease the microhardness of the composite resin samples, which raises a concern about replacement of these restorations due to the effects on physical and mechanical properties.

PMID:37525860 | PMC:PMC10387141 | DOI:10.26650/eor.20231083203

Eur Oral Res. 2023 May 4;57(2):96-102. doi: 10.26650/eor.20231163180.

ABSTRACT

PURPOSE: To evaluate and compare shear bond strength (SBS) of new and recycled metallic brackets bonded to conditioned and reconditioned enamel, using two different adhesive materials.

MATERIALS AND METHODS: 72 extracted sound human premolars were randomly divided into 6 groups. Transbond XT light cured composite (LCC) and Fuji Ortho LC resin-modified glass ionomer (RMGI), were used as adhesive materials. In groups 1 and 2 (control), new brackets were bonded to sound premolars using either LCC or RMGI, respectively. In Groups 3 and 4, new brackets were bonded to reconditioned enamel; and in groups 5 and 6, sandblasted recycled brackets were rebonded to reconditioned enamel. After 5.000 thermal cycles between 5ºC and 55ºC, SBS was evaluated and adhesive remnant on the enamel assessed using the ARI index. Statistical analyses included Shapiro-Wilk, ANOVA, Fligner-Killeen ANOVA and Tukey tests.

RESULTS: The statistical analysis showed no significant difference in SBS comparing control and experimental groups for either new or recycled brackets (p = 0.848). The SBS was significantly higher in brackets bonded with LCC (15.7 MPa) than RMGI (11.6 MPa) (p = 0.006). Adhesive failure was the most frequent, with the adhesive remnant covering more than 50% of the bracket base.

CONCLUSION: No significant differences were observed in SBS using either new or recycled brackets, regardless of the dental surface treatment (conditioned or reconditioned). Significantly higher SBS values were obtained with LCC adhesive. Adhesive failure prevails in all groups.

PMID:37525859 | PMC:PMC10387137 | DOI:10.26650/eor.20231163180

Eur Oral Res. 2023 May 4;57(2):103-107. doi: 10.26650/eor.20231152488.

ABSTRACT

PURPOSE: This study aimed to examine the effect of beverages at different temperatures on the coloring of composites.

MATERIALS AND METHODS: A total of 48 cylindrical samples, 24 of which were prepared from 2 composite materials (G’aenial; Estelite Σ Quick), were included in the study. The sample dimensions were standardized at 2 x 10 mm2. After the polishing, the initial color measurements were performed using a spectrophotometer. The samples were divided into 3 subgroups as distilled water, hot coffee (60 °C) and cold coffee (0 °C) (n=8). During the 7th and 30th days, the samples were immersed in the solutions for 15 min every day. Color measurements were repeated on the 7th and 30th days. Data were analyzed using a two-way analysis of variance, followed by the Tukey post-hoc test (p<0.05).

RESULTS: The highest color change was detected on the 7th and 30th days in the G-aenial anterior microhybrid composite immersed in hot coffee (p<0.001). The application of hot and cold coffee applications did not make a statistically significant difference in the coloration of the Estelite Σ Quick composite samples at the end of the 7th (p=0.346) and 30th (p=910) days.

CONCLUSION: Hot drinks had a more coloring effect on restorations. This coloration was quite evident in the microhybrid composite.

PMID:37525856 | PMC:PMC10387140 | DOI:10.26650/eor.20231152488

Eur Oral Res. 2023 May 4;57(2):75-82. doi: 10.26650/eor.20231134537.

ABSTRACT

PURPOSE: The present study aims to assess the effect of sports on the dental maturity using two different dental age assessment methods and to determine whether there is a significant correlation between dental maturity and body mass index.

MATERIALS AND METHODS: One hundred and thirty-eight students from Sports High School (study group) and 126 from Fine Arts High School (control group) with standard panoramic radiographs were included in the study. Dental age was assessed using Nolla’s and Haavikko’s methods. Demographic information regarding the weekly training hours and sports age of the study group participants was gathered. Body mass index values of all participants were calculated. Factorial analysis of variance and Tukey’s test were performed and the Pearson correlation coefficient was calculated.

RESULTS: The mean age of the students was 15.93 ± 1.13 years for the study group and 15.99 ± 1.09 years for the control group. Mean dental age values were lower than the mean chronological age values in both high schools. The difference between the dental and chronological ages was insignificant in Sports High School (p > 0.05). Differences in the body mass index between high schools and genders were statistically significant (p<0.05). Significant correlations were detected between the sports and dental ages and between dental age and body mass index values.

CONCLUSION: Sports participation could have positive effects on the dental maturity as well as on the bone development.

PMID:37525854 | PMC:PMC10387144 | DOI:10.26650/eor.20231134537

Transgend Health. 2023 Jul 28;8(4):363-370. doi: 10.1089/trgh.2022.0061. eCollection 2023 Aug.

ABSTRACT

PURPOSE: This study aimed to evaluate the relationship between androgens and the retinal thickness by comparing the macular thickness (MT), retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) thickness of female-to-male transgender men (TGM), women with polycystic ovary syndrome (PCOS), and cisgender women (CW).

METHODS: Thirty-four eyes of 34 TGM, 34 eyes of 34 women with PCOS, and 45 eyes of 45 CW were evaluated by optical coherence tomography. One-way analysis of variance and body mass index (BMI)-adjusted one-way analysis of covariance were conducted to test the differences between groups for statistical evaluation.

RESULTS: The parafoveal MT in TGM was significantly higher than women with PCOS and CW (p<0.001 and p=0.022, respectively). After adjusting for BMI, the perifoveal MT in TGM was significantly higher than women with PCOS and CW (p=0.041 and p=0.021, respectively). The nasal RNFL thickness in TGM was significantly higher than women with PCOS and CW (p=0.021 and p=0.009, respectively). The means of average and inferior RNFL, fovea, and the mean of all GCC values were higher in the TGM group than women with PCOS and CW, but these results were not statistically significant.

CONCLUSIONS: In this study, there was a significant difference between the TGM group and the CW group for the thickness of the nasal RNFL and parafoveal and perifoveal macular area. Androgens may have the potential to increase retinal thickness in TGM; however, there is a need for validation in larger study groups. Clinical Trial Registration Number: HNEAH-KAEK 2021/4.

PMID:37525838 | PMC:PMC10387147 | DOI:10.1089/trgh.2022.0061

Transgend Health. 2023 Jul 28;8(4):352-362. doi: 10.1089/trgh.2021.0071. eCollection 2023 Aug.

ABSTRACT

OBJECTIVE: The primary aim of this study was to define characteristics of transgender women seeking gender-affirming voice modification at our voice center. The secondary aim was to evaluate outcome measures, comparing (a) behavioral voice training alone, (b) surgery alone, and (c) combination of behavioral voice training+surgery.

METHODS: Patients seen in a 30-month period, who sought care for gender-affirming voice modification, were included if they were assigned male at birth and identified as female. Patient demographic information, patient quality of life index scores, Trans Woman Voice Questionnaire (TWVQ), and acoustic data were collected before and after intervention.

RESULTS: Sixteen patients met inclusion criteria. The majority of patients were (a) undergoing hormone replacement therapy at initiation of treatment, (b) were presenting in public for over 2 years as female, and (c) had a history of psychological disorders (i.e., gender dysphoria, anxiety, depression, and attention deficit hyperactivity disorder [ADHD]). Increased f0 and decreased TWVQ scores were evident and statistically significant within behavioral voice training cohort and behavioral voice training+surgery cohort. Treatment groups appear similar with respect to average changes; pre- and post-data were not available for surgery only patients. Greater change in f0 was directly correlated with increased number of voice training sessions.

CONCLUSION: There is variability in treatment course for patients seeking gender-affirming voice modification; however, treatment type may not impact outcomes. Increased patient quality of life and increased speaking fundamental frequency were found in this patient cohort.

PMID:37525833 | PMC:PMC10387149 | DOI:10.1089/trgh.2021.0071