Tag: pubmed

BMC Nurs. 2025 Feb 8;24(1):150. doi: 10.1186/s12912-025-02786-7.

ABSTRACT

BACKGROUND: The nursing profession plays a vital role in the provision of healthcare services. The sustainable and high-quality development of nursing work is inseparable from the nurses’ proactive voice behavior. However, in China, comprehensive nationwide survey data on nurse voice behavior remains limited. The present study utilized latent profile analysis to examine the potential profiles, current status, and determinants of nurses’ voice behavior on a national scale, with the aim of formulating targeted intervention strategies to enhance nurses’ capacity for constructive feedback.

METHODS: This study employed a cross-sectional survey design and recruited nurses from medical institutions in China as research participants between November 2023 and January 2024. The survey encompassed three dimensions: individual, environment, and behavior. General demographic questionnaires and voice behavior questionnaires were administered via the questionnaire star platform to collect data for statistical analysis.

RESULTS: A total of 3528 questionnaires from 552 s-class and three-class hospitals hospitals located in 22 provinces, 4 municipalities, 3 autonomous prefectures and 2 special administrative regions throughout China were collected in this study. By analyzing the potential profile of nurses’ voice behavior, three potential categories were formed: low voice behavior group(C1, 21.1% of the total population), medium voice behavior group(C2, 60.9% of the total population), and high voice behavior group(C3, 18.0% of the total population). Factors including night shift work, workload intensity, monthly income, years of nursing experience, professional title, position, health status, personality traits, organizational justice perception, and self-efficacy were found to significantly influence nurses’ expression of their opinions.

CONCLUSION: The voice behavior of nurses in China exhibits a moderate level. Heterogeneity was observed in the voice behavior of nurses, suggesting variations among individuals. The focus of nurse managers should be on nurses belonging to the C1 and C2 group, enabling them to implement early targeted prevention and care based on the distinctive characteristics and influencing factors associated with each latent profile.

PMID:39923084 | DOI:10.1186/s12912-025-02786-7

BMC Oral Health. 2025 Feb 8;25(1):202. doi: 10.1186/s12903-025-05539-9.

ABSTRACT

The current study aimed to assess the effectiveness of the alveolar bone mucosa- periosteal bone flap technique in horizontally augmenting the alveolar ridge during dental implant placement. This retrospective analysis included 20 patients with a total of 45 implants, and was designed to evaluate the alveolar ridge widths both before and after surgery. Preoperative measurements indicated an average alveolar ridge width of 3.62 ± 0.90 mm, which increased to 6.58 ± 1.16 mm postoperatively. Statistical analysis revealed a significant increase in alveolar ridge width following the procedure (P < 0.05), with an average gain of 2.96 ± 1.21 mm. In summary, these findings suggest that the alveolar bone mucosa-periosteal bone flap technique is an effective approach for widening the alveolar ridge while placing dental implants, meriting its consideration for clinical application.

PMID:39923076 | DOI:10.1186/s12903-025-05539-9

BMC Palliat Care. 2025 Feb 8;24(1):37. doi: 10.1186/s12904-025-01674-w.

ABSTRACT

BACKGROUND: Palliative care (PC) in rural China remains underdeveloped, with limited specialized services and significant challenges for healthcare professionals. This study aimed to examine the difficulties in providing PC and their factors from the perspective of healthcare professionals in rural Henan province, China, where specific PC services are currently unavailable.

METHODS: A cross-sectional study was conducted between June and July 2024, using a convenience sample of 255 healthcare professionals from four secondary/tertiary hospitals participated. Data were collected on participants’ demographic characteristics, information on recently deceased cancer patients they had cared for, and PC-related information. PC knowledge and PC difficulties were assessed using the Palliative Care Knowledge Questionnaire-Chinese version (PCKQ-PCN) and the Palliative Care Difficulties Scale (PCDS). Linear regression analysis identified factors associated with PC difficulties.

RESULTS: Among the 255 participants (Mean[age]: 34.82 ± 7.04), 71.8% were females, 57.3% were physicians, and the average work experience was 10.20 years. Regarding PC experience, 48.2% had participated in 1-2 training sessions annually over the past two years, and 32.2% reported a poor understanding of PC. The total PCKQ-PCN mean score was 13.28 ± 2.62, with 25.2% of participants classified as having poor knowledge. The PCDS mean score was 42.58 ± 13.59. Linear regression analysis showed that participating in at least one PC training session every six months (β = -10.66; p = 0.032), having experience caring for seriously ill people at home (β = -6.31; p = 0.024), greater knowledge of symptom management (β = -3.72; p = 0.012), and higher levels of basic knowledge (β = -5.12; p = 0.007) were negatively associated with PC difficulties. Conversely, limited understanding of PC (β = 12.95; p = 0.021), greater knowledge of spiritual care and death education (β = 4.95; p = 0.034), and having new rural cooperative medical insurance (β = 6.36; p = 0.023; β = 3.21; p = 0.042) were positively associated with PC difficulties.

CONCLUSIONS: This study highlights critical gaps in rural China’s PC services, including inadequate training, limited focus on spiritual needs and death education, and disparities in insurance coverage. Targeted training programs in healthcare professionals and policy reforms are urgently needed to improve PC quality and accessibility in rural areas.

PMID:39923072 | DOI:10.1186/s12904-025-01674-w

BMC Womens Health. 2025 Feb 8;25(1):56. doi: 10.1186/s12905-025-03573-x.

ABSTRACT

BACKGROUND: Breast and cervical cancers are the commonest cancers among women. Secondary prevention of cancer through screening minimizes disease burden and improves survival outcomes. Optimizing screening strategies for breast and cervical cancers is a challenge in resource-limited settings with a high population density such as China. Therefore, we aimed at assessing the efficiency of different combined screening strategies for breast and cervical cancers under different budgets in China.

METHODS: Markov cohort model was used to evaluate the cost-effectiveness of 36 strategy combinations for breast and cervical cancer screening with varying screening modality and intervals. The results were used as inputs in the Integer Programming (IP) model to determine the combination of the different screening options under different budgets.

RESULTS: The optimal combination strategy was biennial breast ultrasonography (BUS) and mammography (MAM) in parallel screening and quinquennial human papillomavirus (HPV) for breast and cervical cancer screening under the threshold of the annual per capita social cost investment (PCSCI) (18.80 USD) in China. Using this strategy, the total investment cost for 100,000 females was 1,877,984.50 USD, and the incremental life-years compared with no screening was 3,122 life-years. The optimal combination strategy included annual clinical breast examination (CBE), BUS and MAM in series screening, and biennial thin-layer liquid-based cytology (TCT) and HPV in series screening with the annual PCSCI reaching 37.60 USD. Thereafter, as the cost input continued to increase, the optimal combination strategy remained unchanged, and the sum of incremental life-years and actual input costs did not increase.

CONCLUSIONS: From a social cost-benefit perspective, biennial BUS and MAM in parallel screening, and quinquennial HPV screening is the most efficient combination strategy with limited budget, while annual CBE, BUS and MAM in series screening and biennial TCT and HPV in series screening are the most efficient combination strategy with sufficient budget.

PMID:39923068 | DOI:10.1186/s12905-025-03573-x

Syst Rev. 2025 Feb 8;14(1):38. doi: 10.1186/s13643-025-02784-5.

ABSTRACT

BACKGROUND: Sepsis-associated encephalopathy (SAE) is characterized by brain dysfunction in the context of sepsis and frequently leads to significant cognitive and neurological impairments, as well as an elevated risk of mortality. Accurate diagnosis of SAE is crucial for the timely initiation of optimal treatment and appropriate patient management. Neurogenic biomarkers hold promise as reliable serum diagnostic tools for the detection and longitudinal monitoring of SAE. This meta-analysis seeks to evaluate the diagnostic and prognostic utility of serum neurogenic biomarkers in patients with SAE.

METHODS: The study protocol was registered in the PROSPERO database (CRD42023408312) and conformed to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A meta-analysis was conducted to comprehensively and critically evaluate the existing body of evidence regarding the use of serum neurogenic biomarkers: neuron-specific enolase (NSE), ubiquitin C-terminal hydrolase-L1 (UCH-L1), Tau, S100 calcium-binding protein β (S100β), and glial fibrillary acidic protein (GFAP) for the diagnosis and risk assessment of fatality in SAE. We conducted a systematic search of electronic bibliographic databases, including PubMed, Web of Science, Embase, Cochrane databases, CNKI, CQVIP, and WFSD. The quality and risk of bias of the selected studies were assessed using the QUADAS-2 tool. For biomarkers reported in two or more studies, pooled standardized mean differences and 95% confidence intervals were calculated. Heterogeneity among the included studies was examined using the I² statistic and random-effects model was applied owing to large heterogeneity.

RESULTS: Forty-two studies were included in our meta-analysis. The levels of serum neurogenic biomarkers were significantly higher in patients with SAE as compared to septic patients with no-encephalopathy (NE): NSE (standardized mean difference (SMD) 1.98 (95% CI 1.55-2.42), P < 0.00001); UCH-L1 (SMD 1.75 (95% CI 0.90-2.59), P < 0.0001); Tau (SMD 1.14 (95% CI 1.01-1.28), P < 0.00001); S100β (SMD 1.82 (95% CI 1.45-2.19), P < 0.00001); and GFAP (SMD 3.63 (95% CI 1.85-5.41), P < 0.0001). In addition, significantly lower serum neurogenic biomarkers levels were noted in septic patients with survivors as compared to non-survivors: NSE (SMD – 1.87 (95% CI – 2.43 to – 1.32), P < 0.00001); UCH-L1 (SMD – 1. 71 (95% CI – 2.24 to – 1.19), P < 0.00001); Tau (SMD – 0.57 (95% CI – 0.79 to – 0.35), P < 0.00001); S100β (SMD – 1.34 (95% CI – 1.88 to – 0.80), P < 0.00001). However, no significant differences in serum GFAP levels [SMD -7.98 (95% CI – 22.23-6.27), P = 0.27) were found between the surviving and non-surviving groups.

CONCLUSION: The increased serum neurogenic biomarkers may be predictive of SAE and mortality for septic patients, which are expected to be applied as a reliable blood-based diagnostic tool for detection and longitudinal monitoring in SAE patients. However, results should be interpreted with caution due to the high heterogeneity among studies.

PMID:39923061 | DOI:10.1186/s13643-025-02784-5

BMC Complement Med Ther. 2025 Feb 8;25(1):44. doi: 10.1186/s12906-025-04785-2.

ABSTRACT

BACKGROUND: Stroke is a leading cause of morbidity and mortality globally, with Nigeria having one of the highest stroke mortality rates in Africa. The burden of stroke is particularly high in middle-aged individuals, who are often the primary breadwinners and caregivers in their families. Despite the high burden of stroke in this community, there is a paucity of studies on the knowledge and perception of stroke management practices among middle-aged residents of Otolo community.

AIM: This study investigated the knowledge and perception of middle-aged residents of Otolo community in Nnewi North Local Government Area to stroke management practices; and to identify certain sociodemographic factors that may influence the knowledge and perception of this residents.

METHOD: A total of 191 middle-aged residents of Otolo community in Nnewi North Local Government Area, participated in this cross-sectional study. A self-reported questionnaire was distributed to the participants in the meeting venues, churches and market places with the help of research assistants after filling the consent forms. The data collection lasted for four weeks and it took the average of 12 min to complete each questionnaire. Analysis of the collected data was done using IBM Statistical Package for Social Sciences (SPSS) version 26.

RESULT: The findings of this study revealed that the study participants had a better knowledge of medical stroke management 36 (19%) than traditional stroke care 19(10%). Majority of the participants had a positive perception of medical stroke care129 (68%) than traditional management practices110 (58%). Age, educational status and occupational status were found to have statistically significant association (p < 0.05) with the participants’ knowledge, while the educational attainment and occupational status were the major demographic variables found to be associated (p > 0.05) with the respondents’ perception of stroke management practice.

CONCLUSION: The middle-aged residents of Otolo community had a fair knowledge of medical management of stroke and a poor knowledge of traditional stroke care. Majority of the study respondents had a more positive perception of medical management of stroke as compared to traditional management. Some of the sociodemographic factors found to impact knowledge and perception of this management practices includes age, educational attainment and occupation.

PMID:39923060 | DOI:10.1186/s12906-025-04785-2

BMC Prim Care. 2025 Feb 8;26(1):31. doi: 10.1186/s12875-025-02734-z.

ABSTRACT

BACKGROUND: Interprofessional relationships between general practitioners (GPs) and dental surgeons with a doctorate in dental surgery are essential for the optimal management of the oral health of patients. The objectives of this study were to describe the factors associated with the referral of patients from GPs to dental surgeons in France, and to improve referral practices by establishing a standardized set of items to be included in a referral letter.

METHODS: A nationwide, observational, survey-based, cross-sectional study was conducted from 9 February 2023 to 6 April 2023. Two 13-item questionnaires were sent to GPs and dental surgeons. Data on practitioner characteristics, frequency, and perceived usefulness of medical correspondence between the two healthcare professionals were collected. Candidate items selected by expert medical opinion for a standardized referral letter template were appraised by the responding oral surgeons.

RESULTS: A group of 245 dental surgeons (mean age: 38.2 ± 11.1 years, 64.5% female) and 235 GPs (mean age: 36.8 ± 9.8 years, 71.9% female) participated in this study. Medical correspondence between GPs and dental surgeons was reported to be insufficient by most dental surgeons (91.4%). Dental surgeons agreed that GP correspondence could decrease the occurrence of adverse events linked with dental care (mean score: 7.36 ± 2.4, for a maximum of 10). Only 20% of GPs indicated that they had regular communication with dental surgeons. The physician characteristics under study were not statistically associated with initiating referrals. The items most frequently selected by dental surgeons for inclusion in a template referral letter were the presence of diabetes (99.6%), of immunosuppression (98.8%), and medication by anticoagulant or antiplatelet agents (98.3%).

CONCLUSIONS: Despite known links between oral and general health, most healthcare professionals did not engage in correspondence or referrals with the other specialty. Standardized referral letters could include the list of items for which interest was confirmed by dental surgeons (including presence of diabetes, immunosuppressants and anticoagulants or antiplatelet agents).

PMID:39923052 | DOI:10.1186/s12875-025-02734-z

BMC Oral Health. 2025 Feb 8;25(1):206. doi: 10.1186/s12903-025-05578-2.

ABSTRACT

PURPOSE: The longevity of zirconia restoration depends upon its esthetic, proper occlusion, marginal adaptation, and restoration retention. This study aimed to investigate the combination of 10-MDP-containing primers between the two commercial systems (Scotchbond Universal Plus Adhesive and Panavia V5) and airborne-particle abrasion on shear bond strength (SBS) between zirconia and resin cement.

METHODS: High translucency zirconia discs were sectioned and sintered according to the manufacturer’s recommendations. The specimens were randomly applied with three different primers (Scotchbond Universal Adhesive, Tooth Primer, and Clearfil Ceramic Primer). Then, each group was bonded with Panavia V5 and RelyX™ Universal resin cements. Airborne-particle abrasion on the zirconia surfaces was also conducted using the manufacturer’s bonding protocol for both resin cements. SBS was analyzed by a two-way ANOVA with Tukey’s adjustment for multiple comparisons (α = 0.05).

RESULTS: Panavia V5 exhibited the highest SBS with Scotchbond Universal Adhesive (9.66±2.00 MPa) and Tooth Primer (8.47±2.08 MPa), respectively. As-sintered zirconia luted with primers and RelyX^TM Universal resin cement exhibited lower SBS than that of Panavia V5. In regard to air-abrasion, air-abraded zirconia luted with Tooth Primer and Panavia V5 exhibited statistically significant higher SBS (29.26±3.26 MPa) than other groups (p<0.0001).

CONCLUSIONS: Combining primers from different adhesive cement systems may significantly enhance the bond strength. Zirconia luted with Scotchbond Universal Adhesive and Panavia V5 achieved the highest bond strength when combined with airborne-particle abrasion.

PMID:39923049 | DOI:10.1186/s12903-025-05578-2

BMC Oral Health. 2025 Feb 8;25(1):207. doi: 10.1186/s12903-025-05552-y.

ABSTRACT

OBJECTIVES: The aim of the study was to compare the efficiency of buccal infiltration versus combination of buccal and palatal infiltration to anesthetize maxillary molars with symptomaticirreversible pulpitis, wither lidocaine or articaine are used.

MATERIAL-METHODS: This randomized clinical study was conducted on 80 patients with symptomatic irreversible pulpitis of the maxillary first and second molars. Eighty patients were divided into 4 groups (n = 20). (1) group buccal infiltration with 1.2 ml 4% articaine containing 1:100,000 epinephrine, (2) group buccal infiltration with 1.2 ml 2% lidocaine containing 80,000 epinephrine, (3) group buccal infiltration with 1.2 ml 4% articaine containing 1:100,000 epinephrine and palatinal infiltration with 0.5 ml 4% articaine containing 1:100,000 epinephrine, 4.group buccal infiltration with 1.2 ml 2% lidocaine containing 80.000 epinephrine and palatinal infiltration with 0.5 ml lidocaine containing 80.000 epinephrine. The pain intensity was measured by the Heft-Parker visual analog scale (VAS) before injection, during access cavity preparation and access palatal canal. The data were analyzed by the chi-square and The Kruskal-Wallis tests.

RESULTS: Within the results of the study, no statistically significant difference was found between 4% articaine containing 1:100,000 epinephrine and 2% lidocaine containing 1:80,000 epinephrine in terms of anesthesia effectiveness (p > 0.05). When palatal infiltration anesthesia was applied in addition to buccal infiltration, the pain during entry into the palatal canals was significantly reduced compared to buccal infiltration anesthesia alone (p < 0.05).

CONCLUSIONS: According to the results of this study, it may be recommended to use palatal infiltration anesthesia in addition to buccal infiltration anesthesia, independent of the anesthetic solution, for an effective pulpal anesthesia in maxillary molars with irreversible pulpitis.

CLINICAL TRIAL REGISTRATION: Registration number is “NCT06342869” and date of registration is 2024-04-02.Retrospectively registered.

PMID:39923048 | DOI:10.1186/s12903-025-05552-y

BMC Womens Health. 2025 Feb 8;25(1):55. doi: 10.1186/s12905-025-03584-8.

ABSTRACT

OBJECTIVE: To systematically evaluate existing developed and validated predictive models for stress urinary incontinence after pelvic floor reconstruction.

METHODS: Relevant literature in PubMed, Embase, Web of Science, Cochrane Library, OVID, China National Knowledge Infrastructure(CNKI), Wan Fang Database, VIP database and Chinese Biomedical Literature Service System (SinoMed) were search from inception to 1 March 2024. Literature screening and data extraction were performed independently by two researchers. The chosen study’s statistics included study design, data sources, outcome definitions, sample size, predictors, model development, and performance. The Predictive Modelling Risk of Bias Assessment Tool (PROBAST) checklist was used to assess risk of bias and applicability.

RESULTS: A total of 7 studies containing 9 predictive models were included. All studies had a high risk of bias, primarily due to retrospective design, small sample sizes, single-center trials, lack of blinding, and missing data reporting. The meta-analysis revealed moderate heterogeneity (I² = 68.8%). The pooled AUC value of the validated models was 0.72 (95% CI: 0.65, 0.79), indicating moderate predictive ability.

CONCLUSION: The prediction models evaluated demonstrated moderate discrimination, but significant bias and methodological flaws. The meta-analysis revealed moderate heterogeneity (I² = 68.8%) among the included studies, reflecting differences in study populations, predictors, and methods, which limits the generalizability of the findings. Despite these challenges, these models highlight the potential to identify high-risk patients for targeted interventions to improve surgical outcomes and reduce postoperative complications. The findings suggest that by integrating these models into clinical decision-making, clinicians can better tailor surgical plans and preoperative counseling, thereby improving patient satisfaction and reducing the incidence of postoperative stress urinary incontinence. Future research should follow TRIPOD and PROBAST principles, focus on addressing sources of heterogeneity, improve model development through robust designs, large sample sizes, comprehensive predictors, and novel modelling approaches, and validate tools that can be effectively integrated into clinical decision-making to manage stress urinary incontinence after pelvic floor reconstruction.

PMID:39923045 | DOI:10.1186/s12905-025-03584-8